Inhibition of p38 MAP kinase pathway induces apoptosis and prevents Epstein Barr virus reactivation in Raji cells exposed to lytic cycle inducing compounds期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Inhibition of p38 MAP kinase pathway induces apoptosis and prevents Epstein Barr virus reactivation in Raji cells exposed to lytic cycle inducing compounds

Authors:	Giulia Matusali Giuseppe Arena Alessandra De Leo Livia Di Renzo Elena Mattia

Affiliation:	(1) Dept. of Public Health Sciences, University "La Sapienza", P. le A. Moro 5, 00185 Rome, Italy;(2) Dept. of Experimental Medicine and Pathology, University "La Sapienza", V. le Regina Elena 324, 00161 Rome, Italy

Abstract:	Background EBV lytic cycle activators, such as phorbol esters, anti-immunoglobulin, transforming growth factor β (TGFβ), sodium butyrate, induce apoptosis in EBV-negative but not in EBV-positive Burkitt's lymphoma (BL) cells. To investigate the molecular mechanisms allowing EBV-infected cells to be protected, we examined the expression of viral and cellular antiapoptotic proteins as well as the activation of signal transduction pathways in BL-derived Raji cells exposed to lytic cycle inducing agents.

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