普通肝素和低分子肝素在肺栓塞中的应用

目的比较普通肝素和低分子肝素对急性肺动脉栓塞抗凝治疗的安全性和有效性。方法选择53例急性非大面积肺栓塞患者，根据急性期抗凝治疗的不同，将其分为普通肝素组和低分子肝素组。比较2组患者治疗前后症状、血气分析、螺旋CT肺动脉造影的变化及不良反应。结果治疗后2组患者症状、血气分析均明显改善，缺损肺动脉支数明显减少。普通肝素组的治愈率、有效率、病死率分别为67％，86％，5％，低分子肝素组分别为63％，88％，6％，2组间差异无统计学意义。不良反应发生率普通肝素组高于低分子肝素组。结论普通肝素和低分子肝素均为治疗急性肺动脉栓塞的有效抗凝药物，但低分子肝素较普通肝素更安全。

The application of common heparin and Low-molecular-weight heparin in pulmonary embolism

Objective To compare the efficacy and security of common heparin and Low-molecular-weight heparin in the treatment of the acute pulmonary embolism. Methods The 53 patients of non-massive pulmonary embolism were divided into two groups based the different anticoagulated treatment:the group of common heparin and the group of Low-molecular-weight heparin.The symptoms,the results of blood gas analysis,the spiral computed tomography pulmonary angiography and the adverse reactions were compared between the two groups. Results There were great improvements of the symptoms,the results of blood gas analysis in the two groups after treatment.The branches of embolized pulmonary arteries were reduced greatly.The recovery rate,effective rate and mortality were respectively 67%,86% and 5% in the group of unfractionated heparin. those of the group of Low-molecular-weight heparin were 63%,88% and 6% respectively. There were no statistical significance between the two groups. The adverse reactions were higher in the group of unfractionated heparin than those of the Low-molecular-weight heparin group. Conclusion The common heparin and the Low-molecular-weight heparin are also effective in the treatment of acute pulmonary embolism,but the Low-molecular-weight heparin is much safer than the common heparin.