老年2型糖尿病患者颈动脉粥样硬化与血尿酸水平的相关性研究

目的探讨老年2型糖尿病患者颈动脉内膜-中层厚度(IMT)和血尿酸水平的相关性。方法测定178例老年2型糖尿病患者颈动脉IMT、血尿酸和血压、空腹血糖、甘油三酯(TG),按颈动脉IMT将患者分为内膜正常组、内膜增厚组、斑块形成组及管腔狭窄组,比较各组间血尿酸水平。对颈动脉内膜异常患者,采用多元回归分析,统计颈动脉IMT与血压、血尿酸、空腹血糖、TG之间的关系。结果内膜正常组、内膜增厚组、斑块形成组、管腔狭窄组患者血尿酸水平比较差异有统计学意义(P均<0.01)。颈动脉IMT与血尿酸、TG呈现正相关(P均<0.01)。结论老年2型糖尿病患者颈动脉IMT与血尿酸呈正相关,提示老年2型糖尿病患者血尿酸水平可协助诊断冠心病。

The study on the relationship between carotid atherosclerosis and the level of serum uric acid in elderly type 2 diabetes mellitus

Objective To observe the relationship between the carotid artery intima-media thickness (IMT) and the level of serum uric acid in elderly patients with type 2 diabetes mellitus(T2DM). Methods One hundred and seventy-eight elderly patients with T2DM were measured for carotid artery normal group, intima thicking group, the plaque shaping group and the vascular stenosis group. In the abnormal groups, probable risk factors were analysed by multiple stepwise regression. Results There were significantly differences among these groups (P<0.01). Each group was significantly difference from another group(P< 0.01 ). In the abnormal groups, there was independent relationship of carotid artery IMT with the level of serum uric acid and TG. Conclusions The IMT is correlated with the level of serum uric acid in elderly patients with T2DM. It shows that the level of serum uric acid may be used as a reference index for the prediction of coronary artery disease.