| Stathmin在非小细胞肺癌中表达增强 |
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| 引用本文： | 李雪,李建鹏,哈敏文. Stathmin在非小细胞肺癌中表达增强[J]. 基础医学与临床, 2011, 31(10) |
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| 作者姓名： | 李雪 李建鹏 哈敏文 |
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| 作者单位： | 辽宁医学院附属第一医院肿瘤科,辽宁锦州,121001 |
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| 基金项目： | 辽宁省科学技术计划立项课题(2007225005-13) |
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| 摘 要： | 目的探讨stathmin在非小细胞肺癌(NSCLC)组织中和正常肺组织中的表达,了解其与NSCLC临床病理特征之间的关系。方法用免疫组化与RT-PCR方法,检测43例NSCLC术后癌组织及正常肺组织标本中stathmin蛋白与基因的表达。结果 Stathmin蛋白和基因在NSCLC中阳性表达率分别为62.79%和67.44%,显著高于正常肺组织的16.28%和20.93%(P<0.01),其表达与肿瘤细胞分化程度和有无淋巴结转移有关(P<0.05)。结论 Stathmin在NSCLC的发生发展过程中起了重要作用,可能成为预测NSCLC恶性程度的新的生物学及个体化治疗的敏感指标。
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| 关 键 词： | stathmin 非小细胞肺癌 免疫组化 RT-PCR |
Enhanced expression of stathmin in non-small cell lung cancer |
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| LI Xue,LI Jian-peng,HA Min-wen. Enhanced expression of stathmin in non-small cell lung cancer[J]. Basic Medical Sciences and Clinics, 2011, 31(10) |
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| Authors: | LI Xue LI Jian-peng HA Min-wen |
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| Affiliation: | LI Xue,LI Jian-peng,HA Min-wen(Dept.of Tumour Medicine,the First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001,China) |
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| Abstract: | Objective The expression of Stathmin in non-small cell lung cancer(NSCLC) and in normal tissue the expression and its relationship with clinical and pathological features.Methods Using immunohistochemistry and RT-PCR method,detection 43 patients with NSCLC postoperative cancerous tissue and normal tissue samples in Stathmin protein and mRNA expression.Results Stathmin protein and gene NSCLC expression are respectively 67.44%,62.79% and are significantly higher than those in normal tissues,its expression is ... |
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| Keywords: | stathmin NSCLC immunohistochemistry RT-PCR |
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