榄香烯联合介入治疗中晚期肝癌患者的近期疗效

【目的】观察榄香烯联合肝动脉化疗栓塞术(TACE)介入治疗中晚期肝癌患者的近期疗效。【方法】将63例需行TACE的中晚期肝癌患者随机分为试验组31例和对照组32例。2组均给予TACE介入治疗,对照组单纯采用MAO方案(MMC 4~6 mg/m2,ADM 20~40 mg/m2,L-OHP 50~85 mg/m2),试验组动脉灌注榄香烯乳(400~600 mg/m2)加MAO方案,观察比较2组患者的近期疗效,包括肿瘤的大小、无进展生存期、总生存率和不良反应的发生情况。【结果】(1)2组近期疗效比较:试验组的总反应率(ORR)显著优于对照组,差异有统计学意义(P0.05)。(2)试验组的无疾病生存时间(PFS)为125 d,较对照组的118 d显著延长,差异有统计学意义(P0.05);试验组的中位生存时间(MST)为257 d,较对照组的214 d有延长趋势,但差异无统计学意义(P0.05)。(3)不良反应情况:2组均未出现严重的毒副反应,组间比较,差异无统计学意义(P0.05),但试验组有显示更轻的不良反应倾向。【结论】动脉灌注β-榄香烯联合TACE介入治疗中晚期肝癌可增加肿瘤反应率,延长肿瘤进展时间,不良反应可耐受,并且乏力、腹胀、腹痛等临床症状有缓解倾向,值得推广应用。

Short-term Therapeutic Effect of Elemene Combined with Interventional Therapy for Moderate and Advanced Liver Cancer

Objective To evaluate the short-term effect of elemene combined with transcatheter hepatic arterial chemoembolization (TACE) interventional therapy for the treatment of moderate and advanced liver cancer.Methods A total of 63 patients with moderate and advanced liver cancer were randomized into test group(31 cases) and control group(32 cases). Both groups were given TACE, and additionally, the test group was given intra-arterial infusion of Elemene Emulsion(400-600 mg/m2)together with MAO(Mitomycin C 4-6 mg/m2 , adriamycin 20-40 mg/m2, Oxaliplatin 50-85 mg /m2), and the control group was given intra-arterial infusion of MAO. Short-term effect was evaluated by the clinical outcomes of tumor size, progression-free survival(PFS), total survival rate and adverse reactio n. Results(1)The overall response rate(ORR) in the test group was superior to that in the control group, and the difference was statistically significant(P<0.05) .(2)PFS in the test group covered 125 days, and that in the control group covered 118 days, the difference being significant (P<0.05); the median survival time(MST) in the test group was 257 days, and that in the control group was 214 days,the difference being insignificant(P>0.05).(3) No severe toxic or side effect was found in t he twogroups, the difference being not significant(P>0.05). The test group tended to have milder adverse reaction. Conclusion Intra-arterial infusion Elemene Emulsion combined with TACE interventional therapy is effective in increasing ORR, prolonging PFS, promoting adverse reaction endure and relieving symptoms of weakness, abdominal distension and pain.