子宫内膜癌中孕激素与雌激素受体、Ki-67与C-erbB-2的表达及与病理的相关性分析

目的:探讨子宫内膜癌中孕激素受体(progesterone receptor,PR)、雌激素受体(estrogen receptor,ER)、增殖细胞核抗原67(proliferating cell nuclear antigen 67,Ki-67)与表皮生长因子受体2(epidermal growth factor receptor 2,C-erbB-2)的表达及与病理的相关性。方法:选择77例子宫内膜癌患者的病灶组织蜡块,检测其中PR、ER、Ki-67与C-erbB-2的表达。结果:本组Ⅲ~Ⅳ期病灶PR、ER阳性率低于Ⅰ期与Ⅱ期(P<0.05),Ⅲ~Ⅳ期与Ⅱ期病灶Ki-67与C-erbB-2阳性率高于Ⅰ期(P<0.05)。本组G3类型病灶PR、ER低于G1类型(P<0.05),Ki-67与C-erbB-2的阳性率高于G1类型(P<0.05);G2类型病灶Ki-67阳性率高于G1类型(P<0.05)。本组浸润程度≤1/2的病灶PR、ER阳性率高于浸润程度>1/2病灶(P<0.05),Ki-67阳性率低于浸润程度>1/2病灶(P<0.05);浸润程度≤1/2病灶与>1/2病灶的C-erbB-2阳性率对比差异无统计学意义(P>0.05)。本组有淋巴结转移的病灶PR、ER阳性率低于无淋巴结转移的病灶(P<0.05),Ki-67阳性率高于无淋巴结转移的病灶(P<0.05);有淋巴结转移者与无淋巴结转移者C-erbB-2阳性率对比差异无统计学意义(P>0.05)。本组77例子宫内膜癌患者的Ki-67与C-erbB-2表达呈正相关性(P<0.05)。结论:PR与ER阳性,Ki-67与C-erbB-2阴性的子宫内膜癌患者恶性程度相对较低,分化较佳,4项指标联合检测对评价子宫内膜癌的治疗、诊断及预后具有一定的指导意义。

Expression of progesterone receptor,estrogen receptor,Ki-67 and C-erbB-2 in endometrial carcinoma and correlation with pathology

Objective:To investigate the expression of progesterone receptor (PR),estrogen receptor (ER),proliferating cell nuclear antigen 67 (Ki-67) and epidermal growth factor receptor 2 (C-erbB-2) in endometrial carcinoma and correlation with pathology.Methods:The expression of PR,ER,Ki-67 and C-erbB-2 were detected in 77 patients with endometrial carcinoma.Results:Group Ⅲ ～ Ⅳ stage PR,ER positive rate were lower than Ⅰ with Ⅱ period (P ＜ 0.05),the positive rate of Ki-67 and C-erbB-2 in the stage Ⅲ ～Ⅳ and Ⅱwere higher than that inⅠperiod (P＜0.05).In this group,PR and ER of G3 type were lower than that of G1 (P＜ 0.05),and the positive rate of Ki-67 and C-erbB-2 were higher than that of G1 (P ＜ 0.05).Ki-67 positive rate of G2 type was higher than that of G1 type (P ＜ 0.05).In this group,the PR and ER positive rate of degree of invasion ≤ 1/2 were higher than that of degree of invasion ＞ 1/2,and the positive rate of Ki-67 was lower than that of degree of invasion ＞ 1/2 (P ＜ 0.05).There was no statistically significant difference between degree of invasion ≤ 1/2 and ＞ 1/2 in the positive rate of C-erbB-2 (P ＞ 0.05).In this group,PR and ER positive rate with lymph node metastasis was lower than that without lymph node metastasis (P ＜ 0.05),and Ki-67 positive rate was higher than that with no lymph node metastasis (P ＜ 0.05).There was no statistically significant difference between lymph node metastasis and withoutlymph node metastatic C-erbB-2 positive rate (P ＞ 0.05).The expression of Ki-67 was positively correlated with the expression of C-erbB-2 (P ＜ 0.05) in the patients with intrauterine carcinoma.Conclusion:The malignancy of PR and ER positive,Ki-67 and C-erbB-2 negative endometrial carcinoma is relatively low,and the differentiation is better.The combination of four indicators for diagnosis and prognosis of endometrial carcinoma has a certain guiding significance.