| 淋巴瘤侵犯骨髓的骨髓活检病理学诊断研究进展 |
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| 引用本文： | Liu EB,Chen HS. 淋巴瘤侵犯骨髓的骨髓活检病理学诊断研究进展[J]. 癌症, 2005, 24(11): 1416-1420 |
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| 作者姓名： | Liu EB Chen HS |
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| 作者单位： | 中国医学科学院 中国协和医科大学 血液学研究所血液病医院 病理科,天津,300020;中国医学科学院 中国协和医科大学 血液学研究所血液病医院 病理科,天津,300020 |
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| 摘 要： | 淋巴瘤侵犯骨髓(lymphomabonemarrowinvolvement,LBMI)主要靠骨髓活检确诊。霍奇金淋巴瘤(Hodgkin蒺slymphoma,HL)、非霍奇金淋巴瘤(non-Hodgkin蒺slymphoma,NHL)侵犯骨髓各有其不同病理特点。骨髓中瘤细胞的形态特点、分布方式及免疫表型多数与髓外部位一致,少数又可存在差别。本文比较了各型HL、B-NHL、T-NHL的骨髓侵犯病理学特点,并从形态学、免疫组化及淋巴瘤基因重排检测三方面对LBMI的骨髓活检诊断研究进展进行了综述。
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| 关 键 词： | 淋巴瘤 骨髓侵犯 骨髓活检 病理学 诊断 |
| 文章编号： | 1000-467X(2005)11-1416-05 |
| 收稿时间： | 2004-12-07 |
| 修稿时间： | 2005-09-19 |
Advances of bone marrow biopsy pathology in diagnosing lymphoma bone marrow involvement |
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| Liu En-Bin,Chen Hui-Shu. Advances of bone marrow biopsy pathology in diagnosing lymphoma bone marrow involvement[J]. Chinese journal of cancer, 2005, 24(11): 1416-1420 |
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| Authors: | Liu En-Bin Chen Hui-Shu |
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| Affiliation: | Department of Pathology, Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, P. R. China |
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| Abstract: | The diagnosis of lymphoma bone marrow involvement (LBMI) is mainly based on bone marrow biopsy. Pathology of LBMI in Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) are different. The morphology, distribution patterns and immunophenotype of most tumor cells in bone marrow are consistent with those in extramedullary sites, but few may show some discrepancy. This article compared the pathologic features of LBMI in HL, B-NHL and T-NHL, and reviewed advances of bone marrow biopsy pathology in diagnosing LBMI from the aspects of morphology, immunohistochemistry, and lymphoma gene rearrangement. |
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| Keywords: | Lymphoma Bone marrow involvement Bone marrow biopsy Pathology Diagnosis |
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