|
|||||
|
|
| 载脂蛋白E基因多态性与缺血性脑血管病的关系 | |
| 引用本文： | 邓芝蕙,叶文翔,姜昭,刘明洲,穆红. 载脂蛋白E基因多态性与缺血性脑血管病的关系[J]. 中国临床神经科学, 2000, 8(1): 29-31 |
| 作者姓名： | 邓芝蕙 叶文翔 姜昭 刘明洲 穆红 |
| 作者单位： | 天津第一中心医院脑内科,300192 |
| 摘 要： | 目的载脂蛋白E(apoE)基因多态性对缺血性脑血管疾病(ICVD)发生的影响。方法临床筛选67例缺血性脑血管病病人，利用聚合酶链反应(PCR)技术进行apoE基因位点的扩增，然后用HhaⅠ酶切DNA扩增产物，进行限制性片断长度多态性分析(RFLP)，检测他们的apoE基因型，并与正常对照组比较，并同时检测血脂水平及血流变学指标。结果ICVD组与健康对照组apoE基因型分布无显著差异，不同类型ICVD组apoE基因型分布亦无显著差异。结论apoE基因多态性不是缺血性脑血管病的危险因素。 |
| 关 键 词： | 载脂蛋白E 基因多态性 动脉粥样硬化 缺血性脑血管病 |
| 修稿时间： | 1998-11-25 |
Relationship Between Apolipoprotein E Polymorphism and lschemic Cerebrovascular Disease |
|
| DENG Zhi-Hui,YE Wen-Xiang,JIANG Zhao,LIU Ming-Zhou,MU Hong. Relationship Between Apolipoprotein E Polymorphism and lschemic Cerebrovascular Disease[J]. Chinese Journal of Clinical Neurosciences, 2000, 8(1): 29-31 | |
| Authors: | DENG Zhi-Hui YE Wen-Xiang JIANG Zhao LIU Ming-Zhou MU Hong |
| Affiliation: | DENG Zhi-Hui,YE Wen-Xiang,JIANG Zhao,LIU Ming-Zhou,MU Hong(Neurology Department, Tianjin First Central Hospital.Tianjin 300192) |
| Abstract: | Aim: To investigate the role of apolipoprotein E (apoE) polymorphism in pathogenesis of ischemic cerebrovas- cular disease (ICVD). Methods: We used PCR-RFLP method to detect apoE genotypes of 67 patients with ischemic cere- brovascular disease, and compared it with that of age and sex-matched normal control group. And we detected their plasma lipid levels and hemorheological characteristics at the same time. Results: ApoE polymorphism showed no significant differ- ence between patients and healthy controls. and no difference was found between patients with atherothrombotic stroke and those with lacunar infarction. Conclusion: ApoE polymorphism is not a risk factor for ischemic stroke. |
| Keywords: | apolipoprotein E gene polymorphism atherosclerosis ischemic cerebrovascular disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |