| 氯膦酸二钠新合成工艺 |
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| 引用本文： | 龙仲涛.氯膦酸二钠新合成工艺[J].国际医药卫生导报,2008,14(3):81-83. |
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| 作者姓名： | 龙仲涛 |
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| 作者单位： | 广州白云山明兴制药有限公司,广东广州,510250 |
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| 摘 要： | 目的结合工业化生产条件,制定氯膦酸二钠新合成工艺。方法以二溴甲烷和亚膦酸三乙酯为原料,经亚甲基化、氯化、酸水解和成盐反应得到氯膦酸二钠。结果合成产物的化学结构经元素分析、红外、核磁共振和质谱检测确证,总收率为56%。结论新工艺完全适合工业化生产。
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| 关 键 词： | 氯膦酸二钠 合成 亚膦酸三乙酯 |
| 文章编号： | 1007-1245（2008）03-0081-03 |
| 收稿时间： | 2007-12-11 |
| 修稿时间： | 2007年12月11 |
New Synthesis of Clodronate |
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| LONG Zhongtao.New Synthesis of Clodronate[J].International Medicine & Health Guidance News,2008,14(3):81-83. |
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| Authors: | LONG Zhongtao |
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| Abstract: | Objective To formulate an original craft for industrial production of Clodronate. Methods Clodronate was synthesized by steps of methylenenation,Chloration, acid hydrolysis and salitying from dibromomethane and triethylphosphite.Results The chemical structure of composite production was confirmed by element analysis,IR,MR and PNMR. The overall yield of 56%.Conclusion The original craft of composition suits for industrial production. |
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| Keywords: | Clodronate Synthesis Triethylphosphite |
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