口服抗生素治疗单纯性淋病的疗效观察

目的　评价口服左旋氧氟沙星、头孢克洛在治疗单纯性淋病中的疗效、不良反应。方法　 138例单纯性淋病病人随机分成三组 :A组用左旋氧氟沙星 2 0 0mg ,2次 /d ,共 1周 ;B组用头孢克洛 0 5 g ,3次 /d ,共 1周 ;C组用头孢曲松 2 5 0mg ,单剂量肌注。 结果　A、B、C三组痊愈率分别为 85 94 %、83 33%、87 5 0 % ,三组间差异无显著意义 (P >0 0 5 ) ;B组未发现不良反应 ,A、C两组临床不良反应发生率分别为3 13%、15 6 3%。C组与A组或B组间不良反应差异有非常显著意义 (P <0 0 1)。结论　口服左旋氧氟沙星、头孢克洛治疗单纯性淋病疗效满意、服药方便、安全 ,同时减少了不良反应的发生 ,值得临床推广应用。

Therapeutic effect of oral antibiotic on uncomplicated gonorrhea

Objective To appraise the effect and side effect of levofloxacin and cefaclor on the treatment of uncomplicated gonorrhea.Methods 138 patients with uncomplicated gonorrhea were randomized divided into 3 groups.Group A was treated with levofloxacin 200mg,two times daily for 7 days.Group B was treated with cefaclor 0.5g three times daily for 7 days.Group C was treated with ceftriaxone 250mg intramuscularly for single dose.Results The curative rates in group A,B and C were 85.94%,83.33% and 87.50% respectively.No significant difference was found between three group(P>0.05).The incidence of adverse effects in group A and group C were 3.13% and 15.63% respectively.A significant difference existed between group C and group A or B(P<0.01).Conclusion Levofloxacin and cefaclor can be used in treatment of uncomplicated gonorrhea effectively,conveniently and safely,which may decrease the side effect and popularize clinically.