表没食子儿茶素没食子酸酯的多靶点作用研究进展

表没食子儿茶素没食子酸酯（epigallocatechin-3-gallate，EGCG）作为绿茶中提取的多酚类化合物，具有很强的抗氧化活性。在近30年的研究中，EGCG被证实对多种疾病有治疗作用。特别是在抗肿瘤药物研究领域，EGCG的多靶点抗肿瘤作用已经被广泛认可。EGCG对多种肿瘤细胞的增殖、迁移、转化、代谢具有抑制作用，这种抑制作用主要是通过影响肿瘤发生发展过程中发挥重要作用的多个信号通路（降低信号分子的功能或表达）、影响肿瘤相关基因甲基化、影响细胞膜受体的靶向性结合等方式实现的。同时，近几年有关EGCG与临床抗肿瘤药物联合应用降低肿瘤细胞耐药性、提高药物疗效的研究也成为了多靶点药物研究领域的热点。本文主要对EGCG的多靶点、多途径抗肿瘤作用研究作一总结。

Multi-target effects of epigallocatechin-3-gallate: research advances

Epigallocatechin-3-gallate(EGCG) is the main extraction of tea [Camellia sinesis(Theacacea)].EGCG has extremely strong antioxidant activity.Anticancer activity of EGCG has been an interesting topic over the last decades,especially in the field of multi-target anticancer drug discovery.It is reported that EGCG shows multiple anticancer effects,such as anti-proliferation,anti-angiogenesis,transformation prevention of various cancer cells,cancer cell cycle arrest and inhibition of tumor metastasis.EGCG exerts multi-anticancer effects through regulating several cancer-related cell signal pathways(regulated the function or the expression of key signal proteins),effecting methylation of cancer genes and combination of ligand with membrane receptors.Meanwhile,intensive research has focused on the drug combination of EGCG and other anti-cancer drugs.In this article,the research advances on the multi-target anticancer effects of EGCG are reviewed.