| 质谱联用技术在生物样品分析中的应用 |
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| 作者姓名： | Zhao LS Li Q Guo CW Chen XH Bi KS |
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| 作者单位： | (1. 沈阳药科大学药学院, 辽宁 沈阳 110016; 2. 《中国新药杂志》有限公司, 北京 100120) |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09301-012) |
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| 摘 要： | 质谱分析具有分析范围广、灵敏度高、样品用量少、分析速度快、重复性好、操作简易、损耗低、分离与鉴定可同时进行等优点, 已广泛应用于环境科学、能源化工、生物医药等领域。本文综述了近3年国内外关于质谱联用技术在生物样品分析中应用的文献, 并着重介绍了质谱技术在药物代谢动力学和生物等效性、毒代动力学、药代动力学-药效学、群体药代动力学、药物及代谢物结构确证与裂解规律和代谢组学中的应用, 以期为生物样品分析的进一步发展提供参考。
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| 关 键 词： | 质谱 生物样品分析 药物代谢动力学 生物等效性 毒代动力学 代谢组学 |
Mass spectrometry technology and its application in analysis of biological samples |
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| Zhao LS,Li Q,Guo CW,Chen XH,Bi KS.Mass spectrometry technology and its application in analysis of biological samples[J].Acta Pharmaceutica Sinica,2012,47(2):158-162. |
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| Authors: | Zhao Long-Shan Li Qing Guo Chao-Wei Chen Xiao-Hui Bi Kai-Shun |
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| Institution: | School ofPharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. |
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| Abstract: | With the excellent merits of wide analytical range, high sensitivity, small sample size, fast analysis speed, good repeatability, simple operation, low mobile phase consumption, as well as its capability of simultaneous isolation and identification, etc, mass spectrometry techniques have become widely used in the area of environmental science, energy chemical industry, biological medicine, and so on. This article reviews the application of mass spectrometry technology in biological sample analysis in the latest three years with the focus on the new applications in pharmacokinetics and bioequivalence, toxicokinetics, pharmacokinetic-pharmacodynamic, population pharmacokinetics, identification and fragmentation pathways of drugs and their metabolites and metabonomics to provide references for further study of biological sample analysis. |
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| Keywords: | mass spectrometry biological sample analysis pharmacokinetics bioequivalence toxicokinetics metabonomics |
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