| 药物协同抗生物膜研究进展 |
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| 作者姓名： | Wang CZ Cheng HJ |
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| 作者单位： | (安徽中医学院中西医结合临床学院, 安徽 合肥 230038) |
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| 基金项目： | 国家自然科学基金资助项目(81073127,81173629);安徽省自然科学基金资助项目(090413092);安徽省高校省级自然科学研究重点项目(KJ2010A220) |
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| 摘 要： | 生物膜是细菌或真菌附着于物体表面所形成的有一定结构和功能的菌细胞群体, 其最显著的特征之一是高度耐药性, 单用一种抗菌药物很难将其完全清除, 而不同种类药物的联合应用可有效清除生物膜。本文 现就近年来针对铜绿假单胞菌、葡萄球菌、大肠杆菌、白念珠菌等常见病原菌生物膜的药物协同干预作用作一综述。
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| 关 键 词： | 协同作用 抗生物膜 铜绿假单胞菌 金黄色葡萄球菌 表皮葡萄球菌 大肠杆菌 白念珠菌 |
Advances in the study of synergistic effect of anti-biofilm agents |
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| Wang CZ,Cheng HJ.Advances in the study of synergistic effect of anti-biofilm agents[J].Acta Pharmaceutica Sinica,2012,47(3):339-345. |
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| Authors: | Wang Chang-Zhong Cheng Hui-Juan |
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| Institution: | School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China. ahwcz63@sina.com |
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| Abstract: | Biofilms are communities of surface-associated bacteria or fungi embedded in a self-produced extracellular polymeric matrix that are notoriously difficult to be eradicated and are sources of many recalcitrant infections. Treatment for biofilm infection with any individual drug is always less effective, while the combinations of different types of drugs are superior to monotherapy concerning the removing of biofilms. This paper focus on research progress in recent years for synergistic effect of drugs in combination against biofilms formed by Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Candida albicans. |
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| Keywords: | synergism anti-biofilm Pseudomonas aeruginosa Staphylococcus aureus Staphylococcus epidermidis Escherichia coli Candida albicans |
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