围刺结合刺络拔罐治疗聚合性痤疮的随机对照研究

目的:观察围刺结合刺络拔罐治疗聚合性痤疮的临床疗效,探讨其机制。方法:选取52例聚合性痤疮患者,随机分为针刺组和西药组各26例。针刺组取痤疮局部围刺的基础上,合谷、血海、丰隆、三阴交穴常规针刺,每日治疗1次,同时,结合大椎、肺俞穴刺络拔罐,每周治疗2次;西药组选用异维A酸胶丸口服,10mg/次,每日3次;两组疗程均为4周。治疗结束后观察两组的临床疗效,并于治疗前后分别釆用双抗体夹心ELISA法检测血清白介素-6(IL-6)含量。结果:针刺组26例中,痊愈3例,显效14例,有效6例,无效3例,总有效率为88.5%;西药组26例中,痊愈4例,显效11例,有效7例,无效4例,总有效率84.6%;两组临床疗效比较,差异无统计学意义(P>0.05)。两组治疗后血清IL-6水平较治疗前均明显下降(P<0.01),针刺组较西药组降低更明显(P<0.05)。西药组与针刺组比较有更为明显的不良反应。结论:围刺结合刺络拔罐治疗聚合性痤疮疗效显著,与西药疗效相当;降低血清IL-6水平,调节机体的免疫功能,可能是其促进皮损恢复的机制之一。

Randomized Control Study on the Treatment of 26 Cases of Acne Conglobata with Encircling Acupuncture Combined with Venesection and Cupping

Objective To observe the curative effect of acne conglobata treated by encircling acupuncture combined with ventouse and cupping.Methods A total of 52 acne conglobata patients were randomly divided into acupuncture group(n=26)and Western medicine group(n=26).Patients of acupuncture group were treated with encircling acupuncture around the affected focus.Common acupuncture was applied to Hegu(LI 4),Xuehai(SP 10),Fenglong(ST 40)and Sanyinjiao(SP 6),once daily.Dazhui(GV 14)and Feishu(BL 13)were used for venesection and cupping(twice a week).Patients of medication group were treated with oral administration of Isotretinoin Capsules(10 mg,t.i.d.).The treatment duration of 2 groups was 4 weeks.Serum IL-6 content was detected with double-antibody sandwich elisa enzyme linked immunosorbent assay(ELISA).Results After the treatment,in acupuncture group and Western medicine group,3(11.5%)and 4(15.4%)cases experienced remarkable relief in their signs,14(53.8%)and 11(42.3%)had marked improvement,6(23.1%)and 7(26.9%)had improvement,3(11.5%)and 4(15.4%)failed,with the effective rates being 88.5% and 84.6%,respectively.No significant difference was found between two groups in the therapeutic effect(P>0.05).Self-comparison showed that after the treatment,IL-6 in both groups decreased significantly(P<0.01).The therapeutic effect of acupuncture group was significantly superior to that of Western medicine group in lowering serum IL-6(P<0.05).Conclusion Both acupuncture and medication can effectively promote the recovery of the affected skin,and lower serum IL-6 level in acne conglobata patients.The effect of acupuncture is stronger than that of Isotretinoin Capsules in lowering serum IL-6 content and has fewer adverse effects.