| 3-硝基三氮唑类衍生物TA-201的体外辐射增敏作用 |
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| 引用本文： | 王宜强,李五岭,饶用清,仉文升,李仁利. 3-硝基三氮唑类衍生物TA-201的体外辐射增敏作用[J]. 北京大学学报(医学版), 1993, 0(2) |
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| 作者姓名： | 王宜强 李五岭 饶用清 仉文升 李仁利 |
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| 作者单位： | 北京医科大学放射医学基础教研室(王宜强,李五岭,饶用清),北京医科大学药物化学教研室(仉文升),北京医科大学药物化学教研室(李仁利) |
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| 摘 要： | 本文研究了一种新的三氮唑类衍生物TA-201对体外培养的中国仓鼠肺成纤维细胞系(CHL)的辐射增敏作用。用常规克隆形成法证明,TA-201在0.49、0.95和1.82mmol/L3个浓度下的增敏比分别为1.40、1.78和2.17,增敏作用虽不及MISO,但优于AK-212 3。TA-201对乏氧细胞有选择性的毒性作用,对富氧细胞则无毒性,且可能有一定的辐射防护作用。
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| 关 键 词： | 三氮唑类 TA-201 辐射增敏作用 |
RADIOSENSITIZATION OF CHINESE HAMSTER LUNG FIBROBLAST CELLS BY A 3-NITROTRIAZOLE DERIVATIVE, TA-201, IN VITRO |
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| Wang Yiqiang. RADIOSENSITIZATION OF CHINESE HAMSTER LUNG FIBROBLAST CELLS BY A 3-NITROTRIAZOLE DERIVATIVE, TA-201, IN VITRO[J]. Journal of Peking University. Health sciences, 1993, 0(2) |
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| Authors: | Wang Yiqiang |
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| Affiliation: | Wang Yiqiang Department of the Basic Science of Radiation Medicine |
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| Abstract: | The effects of radiosensitization and cytotoxicity of a 3-nitro-triazole derivative, TA-201, on CHLcells in vitro were exmained hy conventional colony formation method. Enhancement ratios (ERs) of1.40, 1.78 and 2.17 at concentrations of 0.49, 0.95 and 1.82 mmol/L TA-201 were obtained respe-ctively. C_(1.6) estimated from ER-concentration curve was 0.70 mmol/L. In comparison, the radiosensiti-zation, in vitro, of TA-201 seeemed to be greater than that of AK-2123 but less than that of MISO.TA-201 had a preferential cytotoxicity on hypoxic cells to oxic ones, and showed a certain extent ofradioprotection on oxic cells. The fact of reducing or eliminating Dq and N value of cell survivalcurves indicated that TA 201 might be a "shouler" modifier. |
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| Keywords: | TA-201 Triazole derivative Radiosensitization |
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