丹红注射液联合厄贝沙坦治疗早期糖尿病肾病的疗效观察

目的观察丹红注射液联合厄贝沙坦治疗早期糖尿病肾病的疗效。方法64例早期糖尿病肾病患者按数字表法随机分为观察组及对照组各32例，两组均给予控制血糖、改善肾功能等治疗，观察组同时加用丹红注射液、厄贝沙坦治疗，2周后评价疗效。结果观察组总有效率（87．5％）优于对照组（59．4％）（X^2=6．38，P〈0．05），治疗12周后，两组尿蛋白均较治疗前明显减少（t=2．42、2．65，均P〈0．05），其中观察组尿蛋白（0．6±0．1）g／24h]下降程度明显优于对照组（0．7±0．3）g／24h]（t=2．74，P〈0．05）。两组均未发生严重不良反应。结论丹红注射液联合厄贝沙坦治疗早期糖尿病肾病疗效好，可降低尿微量白蛋白，值得临床推广应用。

Observation of the efficacy of Danhong injection combined with irbesartan in treatment of early diabetic nephropathy

Objective To evaluate the effect of the Danhong injection combined with irbesartan in treatment ofearly diabetic nephropathy. Methods 64 patients with early diabetic nephropathy were randomly divided into two groups and the control group 32 cases,two groups were given control of blood sugar and ensure water and electrolyte balance,support therapy,in which 32 cases were also observed red Danhong injection,Ecuador irbesartan treatment,2weeks before evaluation. Results The total effective rate in treatment group was higher than the control group( x2 =6.38 ,P ＜0. 05) ,after 12 weeks of treatment,two groups of urinary protein decreased significantly compared with before treatment, including observation of urine protein was ( 0. 6± 0. 1 ) g/24h, the control group was ( 0. 7 ± 0. 3 ) g/24h,and decreased urine protein level of the observation group was better than the control group( t = 2. 74,P ＜ 0. 05 ). And in the course of treatment, side effects and serious adverse events were not found. Conclusion Danhong injection combined irbesartar, could improve the clinical symptoms, reduce microalbuminuria in treatment of early diabetic nephropathy is worthy of wider application.