表皮生长因子受体和基质金属蛋白酶-9在胃癌组织中的表达及意义

目的探讨表皮生长因子受体（EGFR）和基质金属蛋白酶-9（MMP-9）在胃癌组织中的表达及临床意义。方法采用免疫组化SP法检测80例胃癌组织和30例正常胃组织中EGFR和MMP-9蛋白的表达情况。结果80例胃癌组织中44例EGFR表达阳性（55．O％），明显高于正常胃组织中的6．7％（2／30）（X^2=20．95，P〈0．05）；在淋巴结转移阳性患者胃癌组织中的EGFR表达阳性率为63．6％（35／55），高于淋巴结转移阴性患者胃癌组织的36．0％（9／25）（x。=5．30，P〈0．05）。MMP-9在80例胃癌组织中阳性表达率70．0％（56／80），明显高于正常胃组织中的20．o％（6／30）（X^2=22．18，P〈0．05）；在胃癌不同TNM分期中，（Ⅲ期＋Ⅳ期）组中EGFR和MMP-9的表达均高于其在（Ⅰ期＋Ⅱ期）组中的表达（X^=4．26、5．78，均P〈0．05）。结论EGFR和MMP-9在胃癌组织中高表达，与胃癌TNM分期及淋巴结转移相关，是评估胃癌生物学行为及预后的重要指标。

Expression and clinical significance of EGFR and MMP-9 in gastric cancer

Objective To investigate the expression and clinical significance of EGFR and MMP-9 in gastric cancer. Methods The expression of EGFR and MMP-9 was detected by immunohistochemical method in 80 gastric cancer tissues and 30 normal gastric tissues. Results The expression of EGFR and MMP-9 in gastric cancer tissues were significantly higher than that in normal gastric tissues( x2 =20. 95,22. 18 ,all P ＜0. 05 ). EGFR and MMP-9 expression were correlated with TNM stage ( x2 = 4. 26,5.78, all P ＜ 0. 05 ) and lymph node metastasis ( x2 = 5. 30,5.61 ,all P ＜0. 05). Conclusion EGFR and MMP-9 were over- expressed in gastric cancer,which was closely correlated to TNM stage and lymph node metastasis. It could be used to evaluate the biological behavior and prognosis of gastric cancer.