血清肿瘤标志物联合检测对卵巢肿瘤的诊断价值

目的探讨血清糖蛋白抗原类肿瘤标志物CA125、CA19-9、CA72-4联合检测在卵巢上皮性良、恶性肿瘤及卵巢子宫内膜异位囊肿诊断中的临床价值。方法对28例卵巢上皮性癌患者、15例卵巢子宫内膜异位囊肿患者、42例卵巢良性肿瘤患者及门诊30例健康妇女的血清CA125、CA19-9、CA72-4水平进行回顾性分析。结果卵巢上皮性癌组患者血清CA125、CA19-9、CA72-4水平明显高于卵巢良性肿瘤组、卵巢子宫内膜异位囊肿组及健康对照组（均P〈0．05），卵巢子宫内膜异位囊肿组患者血清CA125、CA19-9、CA72-4水平高于卵巢良性肿瘤组及健康对照组（均P〈0．05）。卵巢癌组血清CA125、CA19-9、CA72-4联合检测阳性率明显高于单独检测阳性率（P〈0．05）。结论血清CA125、CA19—9、CA72-4联合检测可提高诊断阳性率，在卵巢上皮性癌诊断中有重要作用，在卵巢子宫内膜异位囊肿诊断中也有一定的价值。

Clinical value of serum CA 125, CA 19 - 9 and CA 72 - 4 combined determination in diagnosis of ovary tumor

Objective To explore the clinical value of serum CA125, CA19-9 and CA72-4 in ovary epithelial tumor and ovary endometriosis. Methods The detection results of ovary epithelial benign (n = 28) and malignant tumors (n = 15) and ovary endometriosis (n = 42) were retrospectively reviewed and compared with the results of 30 healthy women. Results The expression value of serum CA125 ,CA19-9 and CA72-4 in ovary epithelial cancers was obviously higher than others(all P ＜0.05). And the expression value of serum CA125 ,CA19-9 and CA72-4 in ovary endometriosis was higher than that of ovary benign tumors and the normal group (all P ＜ 0.05). Positive rate of combined determination was higher than that of single marker(P ＜0.05). Conclusion The detection of serum CA125,CA19-9 and CA72-4 had great significance in the diagnosis of ovary epithelial cancers. It could also be used in the diagnosis of ovary endometriosis.