新辅助化疗联合放疗在局部晚期宫颈癌治疗中的作用

目的探讨新辅助化疗（NACT）方案（紫杉醇加顺铂）联合放疗对局部晚期宫颈癌的近期疗效及安全性。方法80例局部复发的晚期宫颈癌患者在知情同意情况下，按患者意愿分为术前行新辅助化疗联合放疗（40例，观察组）和直接手术治疗（40例，对照组）两种治疗方法，分析近期疗效以及两组并发症发生情况。结果观察组总有效率80．0％，对照组总有效率50．0％，两组间差异有统计学意义（X^2=3．47，P〈0．05）；观察组盆腔淋巴结转移率5．0％，对照组为22．5％，两组间差异有统计学意义（X^2=4．78，P〈0．05）；两组不良反应及并发症发生情况差异均无统计学意义（均P〉0．05）。讨论新辅助化疗联合放疗可提高局部晚期宫颈癌的治疗效果，且不良反应少，值得临床推广应用。

Effect of neoadjuvant chemotherapy and radiotherapy in advanced local cervical cancer

Objective To investigate the clinical effect of Paclitaxel and Cisplatin(TP) combined with radiotherapy and clinical security in advanced local cervical cancer. Methods After informed consent,80 patients with cervical canco were studied prospectively,and divided into TP combined with radiotherapy group(40 cases,observation group) ,and surgery group(40 cases,control group). The clinical effect and adverse reactions were analyzed. Results Total effective rate in study group was 80. 0% ,50. 0% in control group,the difference showed statistical significance(x2 =3.47,P ＜0.05).The transfer rate of pelvis lymph node was 5. 0% in observation group,22. 5% in control group, the difference showed statistical significance( x2 = 4. 78 ,P ＜ 0. 05). The difference of adverse reactions between two groups showed no statistical significance( P ＞ 0. 05). Conclusion Clinical effect of Paclitaxel and Cisplatin combined with radiotherapy was obvious in advanced local cervical cancer patients,with little side effect,and could be applied to clinical practice.