化疗药物区域性动脉灌注介入治疗胰腺癌24例临床观察

目的观察化疗药物区域性动脉灌注治疗晚期胰腺癌的疗效。方法46例晚期胰腺癌患者，按给药方式分为观察组（动脉灌注组）24例和对照组（静脉化疗组）22例，观察临床疗效并随访患者的生存情况。结果动脉灌注组客观缓解率为45．83％（11／24），临床受益率58．33％（14／24）；生存时间6—23个月，中位生存期为16个月；静脉化疗组客观缓解率18．18％（4／22），临床受益率27．27％（6／22）；生存时间3～18个月，中位生存期为7个月；动脉灌注组客观缓解率、临床收益率及生存期均优于静脉化疗组，差异均有统计学意义（均P〈0．05）。结论化疗药物区域性动脉灌注介人治疗胰腺癌临床疗效优于静脉治疗组，值得临床进一步推广。

Clinical observation of transarterial infusion chemotherapeutics in treatment of advanced pancreatic carcinoma

Objective To investigate the efficacy and toxicity of infusion of chemotherapeutics through artery to treat advanced pancreatic carcinoma. Methods 46 patients with advanced pancreatic carcinoma were divided into experiment group ( n = 24) and control group ( n = 22). The way of administration of experiment group and control group were through artery or through vein respectively. Results Objective remission rate was 45.83% (11/24) clinical benefit rate was 58.33% (14/24) .median survival time was 16 months(from6 ～23months) in infusion-through-artery group, while those in infusion-through-vein group were18. 18% (4/22) ,27. 27% (6/22) ,7 months (from 3 -18months) respectively. All had significant diferences between two groups (P ＜ 0.05). Conclusion To treat patients with advanced pancreatic carcinoma,transarterial infusion chemotherapeutics was more effective,the toxicity was endurable.