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维持性腹膜透析患者颈动脉硬化及相关因素分析
引用本文:许俊福,罗群. 维持性腹膜透析患者颈动脉硬化及相关因素分析[J]. 中国基层医药, 2011, 18(5): 590-592. DOI: 10.3760/cma.j.issn.1008-6706.2011.05.007
作者姓名:许俊福  罗群
作者单位:宁波市第二医院肾内科,浙江省宁波,315000
摘    要:
目的 研究维持性腹膜透析患者颈动脉硬化及相关因素.方法 收集27例维持性腹膜透析患者及24例配对对照者性别、年龄、体质量、身高、BMI及病程等一般临床资料;抽取静脉血查血红蛋白(Hb)、尿素氮(BUN)、肌酐(SCr)、白蛋白(Alb)、前白蛋白(PA)、C-反应蛋白(CRP)、血浆纤维蛋白原(Fbg)、补体C3、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo-Al)、载脂蛋白B(ApoB)、脂蛋白(a)[LP(a)];采用高分辨率的彩色多普勒超声诊断仪,测定颈动脉粥样斑块的发生率及颈动脉内膜中层厚度(C-IMT).结果 腹透组动脉粥样硬化发生率、斑块多发率和C-IMT显著高于对照组.斑块阳性组患者年龄、TC、TG、LDL-C、LP(a)、透析时间显著高于斑块阴性组(均P<0.05).斑块阳性组较斑块阴性组Hb、Alb及PA均显著降低(均P<0.05),而CRP显著增高(P<0.01).结论 维持性腹透组CRP、LP(a)与C-IMT成正相关,CRP与ALb呈负相关.CRP与年龄、透析时间不相关.维持性腹膜透析患者炎症、营养不良与动脉粥样硬化之间存在着一定联系.

关 键 词:腹膜透析  动脉粥样硬化  炎症  营养不良

The research of carotid atherosclerosis and its relative factors of maintenance peritoneal dialysis patients
XU Jun-fu,LUO Qun. The research of carotid atherosclerosis and its relative factors of maintenance peritoneal dialysis patients[J]. Chinese Journal of Primary Medicine and Pharmacy, 2011, 18(5): 590-592. DOI: 10.3760/cma.j.issn.1008-6706.2011.05.007
Authors:XU Jun-fu  LUO Qun
Affiliation:1.Department of Nephrology, The Second Hospital of Ningbo, Ningbo, Zhejiang 315000, China;)
Abstract:
Objective To explore carotid atherosclerosis and its relative factors of maintenance peritoneal dialysis patients. Methods The general clinical conditions,hematobiochemical parameters and color ultrasound parameters of 27 maintenance peritoneal dialysis patients and 24 controll patients were collecled. General clinical conditions included body weight, height and BMI. Hematobiochemical paremeters included Hb, Alb, LP (a), TC, TG, HDL-C,LDL-C, CRP, plasma fibrinogen, C3, Apo-A 1, Apo-B, LP (a). Color ultrasound parameters included plaque incidence rate,thickness of vascularendothelium(IMT). Results Compared with the controll group,maintenance peritoneal dialysis patients: plaque incidence rate, thickness of vascularendothelium (IMT) increased significantly, Age, TC, TG,LDL-C,LP (a), dialysis time increased significantly in plaque-positive group(all p < 0. 05), while Hb, Alb andPAB decreased significantly (all P < 0.0 5) , CRP increased significantly (P < 0.0 1) . Conclusions In maintenance peritoneal dialysis group,CRP,LP(a) had positive relationship with C-IMT. CRP had negative relationship with ALb. CRP had not relationship with age and dialysis time. There were relationships among malnutrition,inflammation and atherosclerosis in maintenance peritoneal dialysis patients. Interdiction of the relationship may played a very important role in ameliorating the prognosis of the maintenance peritoneal patients.
Keywords:Peritoneal dialysis  Atherosclerosis  Inflammation  Malnutrition
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