| 三萜类化合物抗肿瘤活性研究进展 |
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| 引用本文： | 李娇妹,郑纺,翟丽娟,薛照辉.三萜类化合物抗肿瘤活性研究进展[J].中草药,2014,45(15):2265-2271. |
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| 作者姓名： | 李娇妹 郑纺 翟丽娟 薛照辉 |
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| 作者单位： | 天津大学化工学院 食品科学系, 天津 300072;天津中医药大学中医学院, 天津 300193;天津大学化工学院 食品科学系, 天津 300072;天津大学化工学院 食品科学系, 天津 300072 |
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| 摘 要： | 三萜是一类具有独特空间结构的生物活性天然产物,不仅在抗炎、抗菌、保肝护肾等方面有着重要的应用价值,还具有很强的抗肿瘤活性,极有可能被开发为新一代的抗癌药物。对三萜类化合物抗肿瘤的作用机制、构效关系以及成药特性改良等方面进行综述,可为深入研究三萜的抗肿瘤特性,进一步开发抗癌药物提供科学研究基础。
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| 关 键 词： | 三萜 抗肿瘤活性 作用机制 构效关系 细胞凋亡 |
| 收稿时间： | 2014/1/18 0:00:00 |
Advances in study on antitumor activities of triterpenoids |
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| LI Jiao-mei,ZHENG Fang,ZHAI Li-juan and XUE Zhao-hui.Advances in study on antitumor activities of triterpenoids[J].Chinese Traditional and Herbal Drugs,2014,45(15):2265-2271. |
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| Authors: | LI Jiao-mei ZHENG Fang ZHAI Li-juan and XUE Zhao-hui |
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| Institution: | College of Chemical Engineering, Tianjin University, Tianjin 300072, China;College of Traditional Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 300193, China;College of Chemical Engineering, Tianjin University, Tianjin 300072, China;College of Chemical Engineering, Tianjin University, Tianjin 300072, China |
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| Abstract: | As a kind of bioactive natural products with unique space structure, triterpenoid is widely used in diminishing inflammation, antibacterial, and protecting liver and kidney. Because of the strong ability of antitumor, it is likely to be developed as a new generation of anticancer drugs. In this review, the antineoplastic mechanism, structure-activity relationship, and pharmacophore improvement were summarized for further research on the antitumor properties of triterpenoid. |
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| Keywords: | triterpenoid antitumor activities mechanism structure-function relationship cell apoptosis |
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