| Klotho基因在慢性肾脏病中作用的研究进展 |
| |
| 引用本文： | 梁彦军[综述] 石理华 李辉[审校]. Klotho基因在慢性肾脏病中作用的研究进展[J]. 武警医学院学报, 2013, 0(11): 1039-1042 |
| |
| 作者姓名： | 梁彦军[综述] 石理华 李辉[审校] |
| |
| 作者单位： | 武警后勤学院附属医院肾脏病科,天津300162 |
| |
| 基金项目： | 武警后勤学院博士启动金项目（WHB2013010） |
| |
| 摘 要： | Klotho基因是一种与人类衰老密切相关的基因，其主要在肾脏和脑脉络膜中表达。许多研究证实klotho基因具有多种生物学功能，参与抗肾脏纤维化、钙磷代谢调节，调节离子通道活性，抑制氧化应激及Wnt信号转导等。本文就该基因与慢性肾脏病的关系进行综述，探寻其在慢性肾脏病发生、发展中所发挥的分子生物学机制。
|
| 关 键 词： | Klotho基因 慢性肾脏病 研究进展 |
Progress on the role of Klotho gene in chronic kidney disease |
| |
| Affiliation: | LIANG Yan-jun, SHI Li-hua, LI Hui (Department of Nephrology, Affiliated Hospital of Logistics University of Chinese People＇s Armed Police Forces, Tianjin 300162, China) |
| |
| Abstract: | Klotho gene is closely related with human aging. It is mainly expressed in the kidney and choroids of brain. Many studies have confirmed that klotho gene has many biological functions participating in anti renal fibrosis, calcium and phosphorus metabolic regulation, regulation of channel activity, inhibition of oxidative stress and Wnt signal transduction, etc. In this paper, the relationship between the gene and chronic kidney disease （CKD） are reviewed , exploring the molecular biologisal mechanisms that the Klotho gene plays in the occnn＇ence and development of chronic kidney disease. |
| |
| Keywords: | Klotho gene Chronic kidney disease Research progress |
| 本文献已被 维普 等数据库收录！ |
|
