急性脑梗死患者血清白细胞介素-18检测及临床意义

目的探讨急性脑梗死患者血清白细胞介素-18（IL-18）的水平及临床意义。方法90例急性脑梗死患者按照神经功能缺损程度分为轻型组（29例）、中型组（37例）、重型组（24例），按病灶大小分为小病灶组、中病灶组、大病灶组，以同期健康体检者45例为对照组，观察各组间血清IL-18水平的差异及与病灶大小、病变程度的关系。结果大、中、小病灶组的血清IL-18水平分别为（288．4±59．3）、（237．5±58．0）、（186．9±50．6）ng／L，均明显高于对照组（147．2±42．8）ng／L（均P〈0．05），大病灶组的血清IL-18水平均高于中、小病灶组（均P〈0．05），中病灶组的血清IL-18水平高于小病灶组（P〈0．05）；重、中、轻型组的血清IL-18水平分别为（284．9±57．3）、（233．4±55．9）、（184．5±48．3）ng／L，均明显高于对照组（均P〈0．05），重型组的血清IL-18水平均高于中、轻型组（均P〈0．05），中型组的血清IL-18水平高于轻型组（P〈0．05）。结论血清IL-18水平与脑梗死的病情严重程度相关，IL—18可能参与了缺氧缺血性脑损伤的病理生理过程。

Detection and clinical significance of tnterleukin-18 in patients with acute cerebral infarction

Objective To study the level and clinical significance of serum interleukin-18(IL-18)in patients with acute cerebral infarction.Methods The level of serum IL-18 in patient with acute cerebral infarction(n=90)and normal controls group(n=45)were detected by enzyme linked immunosorbent assay.Results The level of serum IL-18 in large,medium and small lesion group were(288.4±59.3);(237.5±58.0);(186.9±50.6)ng/L respeetlvely,which were significantly higher than those in normal control group.The level of serum IL-18 in control group was(147.2±42.8)ng/L(P＜0.05).large lesion group was significantly higher than that in medium and small lesion group(P＜0.05).medium lesion grouP was significantly higher than that in small lesion group(P＜0.05).The levd of serum IL-18 in heavy,medium and light group were(284.9±57.3);(233.4±55.9);(184.5±48.3)ng/L respectively,which were significantly higher than those in normal control group(P＜0.05);heavy group was slgnificantly higher than that in medium and light group(P＜0.05),medium group was significantly higher than that in light group(P＜0.05).Conclusion The level of serum IL-18 was related to the severity of cerebral infarction,IL-18 may be involved in the pathogenesis of the hypoxic ischemic brain injury.