| 大肠杆菌气管注入致急性肺损伤的实验研究 |
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| 引用本文： | 车玉虎,刘志,董雪松,马涛.大肠杆菌气管注入致急性肺损伤的实验研究[J].中国医科大学学报,2006,35(3):262-264. |
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| 作者姓名： | 车玉虎 刘志 董雪松 马涛 |
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| 作者单位： | 中国医科大学附属第一医院急诊科,辽宁,沈阳,110001 |
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| 摘 要： | 目的：建立气管注入细菌致兔急性肺损伤（ALI）模型,为研究细菌致ALI的致病机制及其治疗提供理论依据.方法：兔分为：细菌注入组（Ⅰ组）,生理盐水注入组（Ⅱ组）,正常对照组（Ⅲ组）.对比观察3组以下指标：血流动力学、呼吸力学、血气分析、支气管灌洗液中的细胞数、蛋白含量、肺组织湿重/干重比及病理检查.结果：Ⅰ组与Ⅱ组、Ⅲ组比较,上述指标,均有明显差异（P均＜0.05）.结论：通过直接气管注入细菌可建立ALI模型.
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| 关 键 词： | 急性肺损伤 气管动物模型 |
| 文章编号： | 0258-4646(2006)03-0262-03 |
| 收稿时间： | 2005-05-31 |
| 修稿时间： | 2005年5月31日 |
Acute lung injury induced by intratracheal instillation of Escherichia coli in rabbits |
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| CHE Yu-hu,LIU Zhi,DONG Xue-song,MA Tao.Acute lung injury induced by intratracheal instillation of Escherichia coli in rabbits[J].Journal of China Medical University,2006,35(3):262-264. |
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| Authors: | CHE Yu-hu LIU Zhi DONG Xue-song MA Tao |
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| Institution: | Department of Emergency, The First Affiliated Hospital, China Medical University, Shenyang 110001, China |
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| Abstract: | Objective: To establish the rabbit model of acute lung injury (ALI) by intratracheal instillation of Escherichia coli , and to study the pathogenesis of bacteria-induced ALI. Methods:Nineteen New Zealand rabbits were divided into 3 groups: group 1 (intratracheally instilled Escherichia coli ), group 2 (intratracheally instilled saline), and group 3 (control group). The indexes, including hemodynamics, respiratory mechanics, blood-gas analysis, cell count in bronchial lavage fluid, protein content, lung wet-to-dry weight ratio, and pathological examination, were determined in these 3 groups. Results:There were significant differences in the above indexes both between group 1 and group 2 and between group 1 and group 3 (both P< 0.05). Conclusion:ALI model can be established by intratracheal instillation of Escherichia coli . |
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| Keywords: | acute tracheal injury trachea animal model rabbit |
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