口腔解毒汤治疗复发性阿弗他溃疡临床疗效观察

目的:观察具有滋阴清热作用的口腔解毒汤内服与外用治疗复发性阿弗他溃疡的疗效。方法:采用口腔解毒汤治疗复发性阿弗他溃疡128例,并与西药治疗对照。结果:近期疗效:治疗7d时中药组溃疡面积、充血面积缩小及疼痛缓解程度缓解明显优于西药组(P0.05,P0.01)。远期疗效:中药组128例,痊愈15例(11.7%),显效68例(53.1%),有效40例(31.3%),总有效率96.1%;西药组100例,痊愈5例(5%),显效28例(28%),有效40例(40%),总有效率73%;两组比较,差异有统计学意义(P0.01)。结论:口腔解毒汤内服与外用具有减轻溃疡周围口腔黏膜充血、立即止痛、加速溃疡面愈合的疗效,并能显著延长溃疡复发间歇期。

Clinical Observation on Treatment of Patients with Recurrent Aphthous Ulcer with Oral Antidote Decoction

Objective: To observe the clinical efficacy of oral taking of Oral Antidote Decoction(OAD), a Chinese recipe for nourishing yin to remove pathogenic fire, combined with external applying of OAD on recurrent aphthous ulcer(RAU). Method: A total of 128 patients with RAU were treated with the combined therapy of OAD, and 100 patients in the control group were treated with Western medicine. The clinical efficacy of the two groups was observed. Result: Short-term effect: the reduction of ulcerated and congestive area as well as the degree of pain alleviation in the treated group on the 7th day after treatment were more significant than those in the control group respectively. Long-term effect: after treatment the cure rate was 11.7%(15/128),the markedly effective rate 53.1%(68/128),the effective rate 31.3%(40/128),and the total effective rate 96.1% in the treated group, while the corresponding rates in the control group were 5%(5/100),28%(28/100),40%(40/100) and 73%,respectively,showing significant difference between the two groups(P<0.01). Conclusion: Oral taking combined with external use of OAD can lessen the congestion of mucous membrane around the ulcerated lesion, quickly alleviate the pain and promote the ulcer healing in patients with RAU, and it also can significantly prolong the interval of RAU recurrence.