| 高脂血症家兔血浆及红细胞膜脂类变化的研究 |
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| 引用本文： | 张凤凯,葛韵琴,程时. 高脂血症家兔血浆及红细胞膜脂类变化的研究[J]. 北京大学学报(医学版), 1990, 0(6) |
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| 作者姓名： | 张凤凯 葛韵琴 程时 |
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| 作者单位： | 北京医科大学生物物理学教研室，北京医科大学生物物理学教研室，北京医科大学生物物理学教研室 北京医科大学临床药理所 |
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| 摘 要： | 高胆固醇血症家兔血浆胆固醇达600mg/100ml以上后,血浆和红细胞膜胆固醇与磷脂的比值较对照组明显上升。通过~3H-胆固醇交换实验,证明红细胞膜胆固醇与磷脂比的增高是由于血浆胆固醇上升所致,推测高胆固醇血症时,红细胞膜胆固醇与磷脂比的改变会引起红细胞膜流动性等物理性质的改变,从而导致微循环不畅等机体损害。
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| 关 键 词： | 高胆固醇血症 胆固醇 磷脂 红细胞膜 |
THE EFFECTS OF HYPERCHOLESTEROLEMIA ON PLASMA AND ERYTHROCYTE MEMBRANE LIPIDS CHANGES IN RABBITS |
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| Zhang Fengkai,et al. THE EFFECTS OF HYPERCHOLESTEROLEMIA ON PLASMA AND ERYTHROCYTE MEMBRANE LIPIDS CHANGES IN RABBITS[J]. Journal of Peking University. Health sciences, 1990, 0(6) |
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| Authors: | Zhang Fengkai et al |
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| Affiliation: | Zhang Fengkai,et al Department of Biophysics |
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| Abstract: | When plasma cholesterol in hypercholesterolemic rabbit reaches 600 mg% the cholesterol/phospha-lipid molecular ratios in plasma and erythrocyte membrane increase obviously compared with that ofnormals. The ~3H-cholesterol exchange experiment demonstrates that the rise of cholesterol/phosphalipidratio in erythrocyte membrane is caused by the rise of plasma cholesterol. Thus, it is supposed that thechange of cholesterol/phosphalipid ratio can induce change in physical propertics such as erythrocytemembrane fluidity, and then proceed to Induce physical injuries such as blocking of microcirculation. |
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| Keywords: | Hypercholesterolemia Cholesterol Phospholipid Erythrocyte membrane |
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