Electrochemical activity determination of trypsin-like enzymes. VIII. Kallikrein and prekallikrein in plasma and whole blood

In-vitro determinations of purified kallikrein on the one hand, of human plasma and whole blood prekallikrein on the other hand have been conducted with the S-2648 electrogenic substrate using the electroanalytical technique. Plasmatic evaluations have been checked photometrically for assessing the reliability of the procedure. Whole blood levels of prekallikrein compare with plasma if the hae-matocrit of the sample is taken into account.