|
|||||
|
|
| 蛇毒神经生长因子对大鼠坐骨神经损伤的修复作用 | |
| 引用本文： | 张素,陈崇宏,郑志竑. 蛇毒神经生长因子对大鼠坐骨神经损伤的修复作用[J]. 福建医药杂志, 2003, 25(4): 147-148 |
| 作者姓名： | 张素 陈崇宏 郑志竑 |
| 作者单位： | 1. 福建医科大学,药理学教研室,350004 2. 福建医科大学,分子医学研究中心,350004 |
| 摘 要： | 目的 研究外源性给予蝰蛇蛇毒提取的神经生长因子(sNGF)对大鼠坐骨神经损伤的修复作用。方法 建立大鼠坐骨神经钳夹模型。sNGF直接作用于损伤的坐骨神经，通过趾间距和Tarlov评分的评定，观察坐骨神经修复的情况。结果 sNGF治疗组的趾间距及Tarlov评分的恢复明显好于空白对照组。结论 局部给予蛇毒神经生长因子能明显改善损伤的坐骨神经功能。 |
| 关 键 词： | 坐骨神经损伤 蛇毒 神经生长因子 大鼠 修复作用 坐骨神经功能 |
| 文章编号： | 1002-2600(2003)04-0147-02 |
Effects of nerve growth factor from the snake venom on repair of injured sciatic nerve in rats |
|
| Zhang Su,Chen Chonghong,Zheng Zhihong Fujian Medical University,Fuzhou ,China. Effects of nerve growth factor from the snake venom on repair of injured sciatic nerve in rats[J]. Fujian Medical Journal, 2003, 25(4): 147-148 | |
| Authors: | Zhang Su Chen Chonghong Zheng Zhihong Fujian Medical University Fuzhou China |
| Affiliation: | Zhang Su,Chen Chonghong,Zheng Zhihong Fujian Medical University,Fuzhou 350004,China |
| Abstract: | Objective To investigate the effects of snake nerve growth factor(sNGF)on repair of sciatic nerves in rats.Methods Animal models of the crushed sciatic nerve were established in SD rats.The sNGF could be used in the crushed sciatic nerve.To investigate the toe spreading reflex(TSR)and the Tarlov function value in order to observe the effects of NGF on the functional recovery of sciatic nerve following crush injury.Results The TSR and Tarlov function value of NGF groups were recovered better than the group without sNGF.Conclusion sNGF could significantly enhance the recovery of the function of the injured sciatic nerve. |
| Keywords: | Nerve growth factor Sciatic nerve venom |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |