原发性肝癌患者血清血管内皮生长因子检测及临床意义

目的探讨血清血管内皮生长因子（VEGF）与原发性肝癌（PHC）发生、发展、转移、疗效及预后的关系。方法采用ELISA法检测了50例PHC、13例良性肝肿瘤患者和30例正常对照组血清VEGF水平。结果PHC患者血清VEGF水平明显高于正常人及良性肝肿瘤患者（P〈0．01），并与肿瘤直径、AFP水平、有无腹腔积液、有无肝外转移、临床分期及治疗效果有关。结论PHC患者血清VEGF水平在一定程度上可反映肝癌发生、发展、转移情况及治疗效果．可能成为预测肝癌转移及疗效的有效指标。

Clinical significance of serum vascular endothelial growth factor in patients with primary hepatic carcinoma

Objective To study the relationships between serum vascular endothelial growth factor(VEGF) and the development,metastasis,curative effect and prognosis of primary hepatic carcinoma(PHC).Methods The serum VEGF in 50 patients with PHC, 15 patients with various benign liver tumor and 30 cases normal control were determined by ELISA method before and after treatment. Results The serum VEGF level of patients with PHC was significantly higher than that in control groups and the patients with various bemign liver tumour(P<0.01). and correlated with tumor diameter,level of AFP,ascites,metastasis,clinical stages and curative effect.Conclusion The serum VEGF levels could be a marker of occurremce, stage and metastasis of the PHC and may play a role in biological character of hepatoma cell and curatve effect.