| 高效液相色谱法测定头孢丙烯干混悬剂的溶出度 |
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| 引用本文： | 蔡旭萍,林茜,朱惠卿,葛孝忠,吴彩萍.高效液相色谱法测定头孢丙烯干混悬剂的溶出度[J].中国药业,2012,21(2):38-39. |
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| 作者姓名： | 蔡旭萍 林茜 朱惠卿 葛孝忠 吴彩萍 |
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| 作者单位： | 1. 浙江普洛康裕制药有限公司,浙江,金华,322118
2. 浙江北生药业汉生制药有限公司,浙江,金华,322100 |
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| 摘 要： | 目的 建立测定头孢丙烯干混悬剂溶出度的高效液相色谱法.方法 采用桨法,以水900 mL为溶出介质,转速为50 r/min,溶出时间为30min,用高效液相色谱法进行测定.结果 所用方法线性关系良好,平均回收率为99.13%,RSD=0.25%(n=9).结论 该法简便、准确,可为头孢丙烯干混悬剂溶出度的测定提供参考.
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| 关 键 词： | 头孢丙烯干混悬剂 溶出度 高效液相色谱法 |
Dissolution Rate Determination of Cefprozil for Suspension by HPLC |
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| Cai Xuping,Lin Qian,Zhu Huiqing,Ge Xiaozhong,Wu Caiping.Dissolution Rate Determination of Cefprozil for Suspension by HPLC[J].China Pharmaceuticals,2012,21(2):38-39. |
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| Authors: | Cai Xuping Lin Qian Zhu Huiqing Ge Xiaozhong Wu Caiping |
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| Institution: | 1.Zhejiang Apeloa Kangyu Pharmaceutical Co.,Ltd.,Jinhua,Zhejiang,China 322118; 2.Hansheng Pharmaceutical Co..Ltd.,Zhejiang Beisheng Pharmaceuticals,Jinhua,Zhejiang,China 322100) |
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| Abstract: | Objective To establish a testing method for determining the dissolution rate of cefprozil for suspension.Methods The stirring paddle method was adopted to treat the product with 900 mL water as dissolution medium,the rotating speed at 50 r/mim and the dissolving time of 30 min.And then The HPLC method was performed for testing.Results The obtained linear relationship was well.The average recovery rate was 99.13%and RSD was 0.25%（n=9）.Conclusion This method is simple and accurate,which can be used as the basis of determining the dissolution rate of cefprozil for suspersion. |
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| Keywords: | Cefprozil for Suspension dissolution rate HPLC |
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