| 内皮细胞caveolae,caveolin-1的生理功能 |
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| 引用本文： | 潘虹,王庭槐.内皮细胞caveolae,caveolin-1的生理功能[J].医学综述,2006,12(22):1345-1347. |
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| 作者姓名： | 潘虹 王庭槐 |
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| 作者单位： | 中山大学基础医学院生理学教研室,广州,510080 |
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| 摘 要： | Caveolae是一种直径为50~100nm的细胞质膜表面特异性内陷结构。Caveolin-1是一个相对分子质量为21×103~24×103的完整膜蛋白,是组成caveolae的主要蛋白质成分。它们富含于多种类型的细胞内,其中内皮细胞是含量最丰富的细胞类型之一。内皮细胞caveolae与caveolin-1在物质转运、内皮组织通透性、动脉粥样硬化发生发展以及信号转导过程中发挥着重要的调节作用。
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| 关 键 词： | caveolae caveolin-1 内皮细胞 生理功能 |
| 文章编号： | 1006-2084（2006）22-1345-03 |
| 收稿时间： | 2006-04-22 |
| 修稿时间： | 2006-08-06 |
The Physiological Function of Endothelial Caveolae and Caveolin-1 |
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| PAN Hong,WANG Ting-huai.The Physiological Function of Endothelial Caveolae and Caveolin-1[J].Medical Recapitulate,2006,12(22):1345-1347. |
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| Authors: | PAN Hong WANG Ting-huai |
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| Abstract: | Caveolae is a kind of specific invagination on the surface of cytomembrane about 50～100 nm in its diameter.Caveolin-1 is a kind of integral memebrane protein about 21×10~3 to 24×10~3 in its relative molecular mass,which is the main protein constituting caveolae.They are extremely abundant in many cell types,in which endothelial cell is one of the types lying number one.Endothelial caveolae and caveolin-1 play an important reguational effect in the transport of substances,endothelial permeability,the genensis and development of atherosclerosis and signal transduction. |
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| Keywords: | caveolae caveolin-1 |
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