苯丙胺类中枢兴奋剂依赖者事件相关电位P_(300)波形特点及其分析研究

目的:探讨苯丙胺类中枢兴奋剂(ATS)依赖者事件相关电位P300主要指标的变化特点及其与临床精神症状的相互关系。方法:对40例ATS依赖病例(研究组)和30例本院职工或家属(对照组)进行事件相关电位P300的检测,并使用症状自评量表对研究组进行评定。结果:ATS依赖者靶刺激N2潜伏期(245.74ms±s12.60ms)、P3潜伏期(318.46ms±s18.77ms)、P2-N2峰间潜伏期(69.13ms±s10.76ms)较正常对照组(238.81ms±s13.70ms,310.27ms±s11.41ms,65.23ms±s11.58ms)延长,均P<0.05,P3波幅(5.31ms±s2.39ms)低于正常对照组(9.50ms±s1.58ms),P<0.01;伴有精神病性症状的ATS依赖者P3波幅(4.64uv±s2.96uv)低于不伴有精神病性症状的依赖者波幅(5.73uv±s3.66uv),P3潜伏期(320.36ms±s19.23ms)较不伴有精神病性症状的依赖者(312.73ms±s18.19ms)延长,P<0.05;N2潜伏期与焦虑分(r=-0.366)、偏执分呈负相关(r=-0.386);P3潜伏期与精神病性症状分(r=-0.430)、躯体化分呈负相关(r=-0.397);P3波幅与精神病性症状分呈负相关(r=-0.486)。结论:ATS依赖者存在明显的认知功能损害,其中N2潜伏期、P3潜伏期及P3波幅与ATS依赖者的多种临床症状呈相关性。

ANALYSIS STUDY OF THE VARIABILITY FEATURE OF P300 IN PATIENTS WITH AMPHETAMINE TYPE STIMULANTS DEPENDENCE

Objective:To explore the variability feature of P_(300),and the correlation between P_(300) and clinical manifestation in patients with amphetamine type stimulants(ATS)dependence.Methods:Forty ATS dependent patients and 30 normal controls were assessed by auditory event-related potential P_(300) with Galileo Sirius 32 channels digital evoked potential systems and SCL-90.Results:In comparison with normal controls(N_2 238.81±s 13.70 ms,P_3 310.27 ms±s 11.41 ms,P_2-N_2(65.23 ms±s 11.58 ms,P_3 9.5 0 ms±s 1.58 ms),ATS dependent patients had longer latency of N_2(245.74 ms±s 12.60 ms),P_3(318.46 ms±s 18.77 ms)and inter-peak latency of P_2-N_2(69.13 ms±s 10.76 ms),P<0.05,and lower amplitude of P_3(5.31 ms±s 2.39 ms),P<0.01.ATS dependent patients with psychotic symptoms had lower amplitude of P_3(4.64 uv±s 2.96 uv)and longer latency of P_3(320.36 ms±s 19.23 ms) than those without psychotic symptoms(5.73 uv±s 3.66 uv,312.73 ms±s 18.19 ms),P<0.05; latency of N_2 was inversely correlated to anxiety(r=-0.366)and paranoia(r=-0.386);latency of P_3 was inversely correlated to psychiatric symptoms(r=-0.430),somatization(r=-0.397),amplitude of P_3 was inversely correlated to psychiatric symptom(r=-0.486).Conclusion:ATS dependent patients suffer from cognitive dysfunction.Latency of N_2,P_3 and amplitude of P_3 have different correlations with many psychotic symptoms.