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| GLP-1受体激动剂超说明书用药情况调查及合理性分析 | |
| 引用本文： | 苏芬丽,沈创鹏,麦美琪,利亭婷,孙旭,蔡庆群. GLP-1受体激动剂超说明书用药情况调查及合理性分析[J]. 中国现代应用药学, 2017, 34(11): 1611-1615 |
| 作者姓名： | 苏芬丽 沈创鹏 麦美琪 利亭婷 孙旭 蔡庆群 |
| 作者单位： | 广州中医药大学第一附属医院, 药学部, 广州 510405,广州中医药大学第一附属医院, 内分泌科, 广州 510405,广州中医药大学第一附属医院, 内分泌科, 广州 510405;中山市中医院内分泌科, 广东 中山 528400,广州中医药大学第一附属医院, 药学部, 广州 510405,广州中医药大学第一附属医院, 药学部, 广州 510405,广州中医药大学第一附属医院, 药学部, 广州 510405 |
| 摘 要： | 目的 了解GLP-1受体激动剂超说明书用药情况，促进临床合理用药。方法 采用回顾性调查法，抽取内分泌科2015年12月3日-2016年12月14日使用过GLP-1受体激动剂进行治疗的住院病例，按照药品说明书，判断其超说明书用药情况，对超说明书用药进行分类和统计，并评价其合理性。结果 共调查内分泌科住院患者51例，有97例次存在超说明书用药情况，其中超适应证47例次（48.45%），主要表现在联合用药方面，另有50例次（51.55%）属于用法用量超说明书。结论 GLP-1受体激动剂在临床超说明书使用的现象较普遍，某些有其合理性和必要性，但也有不合理用药情况，临床需引起高度重视。 |
| 关 键 词： | GLP-1受体激动剂 超说明书用药 合理用药 |
| 收稿时间： | 2017-05-14 |
| 修稿时间： | 2017-08-27 |
Investigation and Rationally Analysis of Off-label Drug Use of GLP-1 Receptor Agonist |
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| SU Fenli,SHEN Chuangpeng,MAI Meiqi,LI Tingting,SUN Xu and CAI Qingqun. Investigation and Rationally Analysis of Off-label Drug Use of GLP-1 Receptor Agonist[J]. The Chinese Journal of Modern Applied Pharmacy, 2017, 34(11): 1611-1615 | |
| Authors: | SU Fenli SHEN Chuangpeng MAI Meiqi LI Tingting SUN Xu CAI Qingqun |
| Affiliation: | First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Pharmacy of Department, Guangzhou 510405, China,First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Endocrine Department, Guangzhou 510405, China,First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Endocrine Department, Guangzhou 510405, China;Endocrine Department, Hospital of Traditional Chinese Medicine of Zhongshan, Zhongshan 528400, China,First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Pharmacy of Department, Guangzhou 510405, China,First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Pharmacy of Department, Guangzhou 510405, China and First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Pharmacy of Department, Guangzhou 510405, China |
| Abstract: | OBJECTIVE To investigate the situation of off-label drug use of GLP-1 receptor agonist, so as to promote rational clinical drug use. METHODS By a retrospective survey method, all inpatients in Endocrine Department used GLP-1 receptor agonist from December 3, 2015 to December 14, 2016 were selected, and the situation of off-label drug use was analyzed. RESULTS A total of 51 cases were analyzed, 97 had off-label drug use. The main type of off-label drug use were 47(48.45%) in indications, especially in drug combination, and 50(51.55%) in dose. CONCLUSION The off-label drug use of GLP-1 receptor agonist was common in clinical, and some were reasonable and necessary; yet there were still some irrational phenomenon, which need the close attention by the clinic. |
| Keywords: | GLP-1 receptor agonist off-label drug use rational drug use |
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