丹参川芎嗪注射液联合阿托伐他汀治疗急性脑梗死的疗效观察

目的探究丹参川芎嗪注射液联合阿托伐他汀钙片治疗急性脑梗死的临床疗效。方法选取2013年6月—2016年6月在西安交通大学附属红会医院治疗的急性脑梗死患者203例为研究对象,患者入院后按计算机随机号码分为对照组(98例)和治疗组(105例)。对照组口服阿托伐他汀片,20 mg/次,1次/d。治疗组在对照组基础上静脉滴注丹参川芎嗪注射液,10 m L加入到5%葡萄糖注射液250 m L中,1次/d。两组均连续治疗14 d。观察两组的临床疗效,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(ADL)评分、血液流变学指标和随访情况。结果治疗后,对照组和治疗组的总有效率分别为85.7%、96.2%,两组比较差异有统计学意义(P0.05)。治疗14 d后,两组NIHSS评分均显著降低,而ADL评分均显著上升,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于同期对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组血小板聚集率、血浆纤维蛋白原和血浆黏度明显下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗90、180 d后,两组ADL评分均显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组ADL评分明显高于对照组,两组比较差异具有统计学意义(P0.05)。结论丹参川芎嗪注射液联合阿托伐他汀片治疗急性脑梗死具有较好的临床疗效,可改善脑神经功能,调节血液流变学指标,改善预后,具有一定的临床推广应用价值。

Clinical observation of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with atorvastatin in treatment of acute cerebral infarction

Objective To investigate the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Atorvastatin Calcium Tablets in treatment of acute cerebral infarction. Methods Patients (203 cases) with acute cerebral infarction in Red Cross Hospital Affiliated to Xi''an Jiao Tong University from June 2013 to June 2016 were randomly divided into control group (98 cases) and treatment group (105 cases). Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NIHSS scores, ADL scores, blood rheology indexes, and follow-up in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.7% and 96.2%, respectively, and there was difference between two groups (P<0.05). After treatment for 14 d, the NIHSS scores in two groups were significantly decreased, but the ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, platelet aggregation rate, plasma fibrinogen, and plasma viscosity in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment for 90, 180 d, the ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the ADL score in the treatment group was significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Atorvastatin Calcium Tablets has clinical curative effect in treatment of acute cerebral infarction, can improve brain nerve function, regulate blood rheology index, and improve the prognosis, which has a certain clinical application value.