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| 神经生长因子对周围神经损伤的保护作用 | |
| 引用本文： | 吴俊芳,屈志炜,卫国,张均田. 神经生长因子对周围神经损伤的保护作用[J]. 药学学报, 1998, 33(3): 180-183 |
| 作者姓名： | 吴俊芳 屈志炜 卫国 张均田 |
| 作者单位： | 中国医学科学院中国协和医科大学药物研究所 |
| 摘 要： | 以小鼠化学性交感神经末梢损伤、家兔尺神经机械损伤为模型及用新生大鼠背根神经节体外无血清培养法,研究神经生长因子(NGF)对周围神经损伤及感觉神经元的保护作用。结果表明,NGF剂量依赖地提高小鼠颌下腺去甲肾上腺素残留率,提高损伤后兔C7,T1背根神经节的细胞数,显著促进新生大鼠背根神经节突起的生长。结果提示,NGF对周围神经损伤有明显的保护作用,并对感觉神经元有很强的神经营养作用。 |
| 关 键 词： | 神经生长因子 去甲肾上腺素 尺神经损伤 背根神经节 |
| 收稿时间： | 1997-05-16 |
The protective effects of nerve growth factor on peripheral nerve injury] |
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| Wu Junfang,Qu Zhiwei,Wei Guo and Zhang Juntian. The protective effects of nerve growth factor on peripheral nerve injury][J]. Acta pharmaceutica Sinica, 1998, 33(3): 180-183 | |
| Authors: | Wu Junfang Qu Zhiwei Wei Guo Zhang Juntian |
| Affiliation: | Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050. |
| Abstract: | The protective effects of nerve growth factor (NGF) on peripheral nerve injury and sensory neuron growth were studied in three models: peripheral sympathetic nerve injury induced by intraperitoneal injection of 6-hydrodopamine (6-OHDA), mechanically injured ulnar nerve and cultured dorsal root ganglion (DRG) of newborn rats in vitro. The results indicate that NGF dose-dependently increased norepinephrine content in mouse submandibular gland and cell numbers of C7 (seventh cervical vertebra), T1 (first thoracic vertebra) dorsal root ganglion in rabbits, and also dramatically promoted the growth of neuronal projections in cultured DRG. These results suggest that NGF has significant neuroprotective action in peripheral nerve injury and a strong neuronutrition on sensory neuron. |
| Keywords: | Nerve growth factor Norepinepherine Nerve injury Dorsal root ganglion |
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