| 石墨炉原子吸收光谱法测定阿伐斯汀中残留钯元素 |
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| 引用本文： | 王超,张平,王刚.石墨炉原子吸收光谱法测定阿伐斯汀中残留钯元素[J].安徽医药,2009,13(8):890-892. |
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| 作者姓名： | 王超 张平 王刚 |
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| 作者单位： | 安徽医科大学药学院,安徽,合肥,230032;安徽医科大学药学院,安徽,合肥,230032;安徽医科大学第一附属医院药剂科,安徽,合肥,230022;合肥合源医药科技股份有限公司,安徽,合肥,230088 |
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| 摘 要： | 目的建立一种石墨炉原子吸收光谱法测定残留钯元素的方法。方法阿伐斯汀原料药经前处理和稀释后,直接用石墨炉原子吸收法测定。结果残留钯元素标准曲线的线性范围为0.00-400.0μg.L-1,相关系数为0.9999,方法的检出限为12.5μg.L-1。方法回收率在96.8%-102.6%之间,RSD=2.2%（n=9）。结论该方法操作简便、迅速,具有良好的精密度和准确度,可用于阿伐斯汀中残留钯的测定
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| 关 键 词： | 石墨炉-原子吸收光谱法 钯 阿伐斯汀 |
Determination of residual palladium in acrivastine by graphite furnace atomic absorption spectrometry |
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| WANG Chao,ZHANG Ping,Wang Gang,Ren Ya-wei.Determination of residual palladium in acrivastine by graphite furnace atomic absorption spectrometry[J].Anhui Medical and Pharmaceutical Journal,2009,13(8):890-892. |
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| Authors: | WANG Chao ZHANG Ping Wang Gang Ren Ya-wei |
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| Institution: | WANG Chao1,ZHANG Ping,Wang Gang3,Ren Yawei (School of Pharmacy,Anhui Medical University,Hefei,230032,China Pharmacy Department,The First Affiliation Hospital of Anhui Medical University,Hefei 230022,China Hefei Con-Source Medicine Technology Corp,Hefei 230088,China) |
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| Abstract: | Aim To establish a method for determination of residual palladium in acrivastine by graphite furnace atomic absorption spectrometry（GF-AAS）.Methods： Residual palladium in acrivastine was directly determined by GFAAS after the samples were processing and diluted.Results In this method,the linear range was from 0.0 to 400.0 μg·L-1,the relevant coefficient are 0.9999,the detection limit of the method was 12.5 mg·L-1.The average recoveries of samples were between 98.6%～105.9%,RSD =2.97%（n=9）.Conclusion： This method is simple, rapid, accurate and precise. It can be applied in the determination of residual palladium in acrivastine. |
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| Keywords: | GF-AAS Pd activastine |
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