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| 六味地黄汤醇提水洗脱部位对小鼠阴虚模型的影响 | |
| 引用本文： | 刘继平,兰洲,傅强,罗建光,马世平,孔令义.六味地黄汤醇提水洗脱部位对小鼠阴虚模型的影响[J].西北药学杂志,2011,26(4):265-267. |
| 作者姓名： | 刘继平 兰洲 傅强 罗建光 马世平 孔令义 |
| 作者单位： | 1. 中国药科大学中药药理教研室,江苏,南京,210009;陕西中医学院药理教研室,陕西,咸阳,712046 2. 中国药科大学中药药理教研室,江苏,南京,210009 3. 中国药科大学天然药化教研室,江苏,南京,210009 |
| 基金项目： | "重大新药创制"科技重大专项 |
| 摘 要： | 目的观察六味地黄汤醇提水洗脱部位对阴虚小鼠体质量、免疫功能、肝组织氧化指标和cAMP、cGMP、T3、T4含量的影响,评价其滋阴作用。方法将小鼠每日灌胃给予甲状腺片(150 mg·kg-1)和利血平(1 mg·kg-1)致阴虚模型,同时给予治疗药物,7 d后检测小鼠体质量增长率、胸腺、脾指数及血浆中cAMP、cGMP、T3、T4,肝匀浆SOD、GSH-Px和MDA等,观察六味地黄汤醇提水洗脱部位对阴虚型小鼠的影响。结果六味地黄汤醇提水洗脱部位能提高阴虚小鼠体质量增长率、胸腺和脾脏指数,降低阴虚小鼠肝组织中SOD和GSH-Px活性,升高MDA含量,降低血清cAMP、T3、T4含量和cAMP/cGMP比值,高剂量组与模型组比较有统计学意义(P<0.05,P<0.01);六味地黄汤亦可改善以上各项指标,但与模型组相比无统计学意义。结论六味地黄汤醇提水洗脱部位具有显著滋阴作用,优于传统六味地黄汤煎剂。 |
| 关 键 词： | 六味地黄汤醇提水洗脱部位 阴虚模型 cAMP/cGMP 抗氧化 |
Effect of ethanol-aqueous extract of Liuweidihuang broth on the Yin-deficiency models in mice |
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| LIU Jiping,LAN Zhou,FU Qiang,LUO Jianguang,MA Shiping,KONG Lingyi.Effect of ethanol-aqueous extract of Liuweidihuang broth on the Yin-deficiency models in mice[J].Northwest Pharmaceutical Journal,2011,26(4):265-267. | |
| Authors: | LIU Jiping LAN Zhou FU Qiang LUO Jianguang MA Shiping KONG Lingyi |
| Institution: | LIU Jiping1,2,LAN Zhou1,FU Qiang1,LUO Jianguang3,MA Shiping1,KONG Lingyi3(1.Department of Pharmacology of Chinese Materia Medica,China Pharmaceutical University,Jiangsu Nanjing 210009,China,2.Department of Pharmacology,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,3.Department of Natural Medicinal Chemistry,China) |
| Abstract: | Objective To evaluate the Yin-nourishing action of ethanol-aqueous extract of Liuweidihuang broth(LW) on body weight,immune function,liver oxidation indexes and levels of cAMP,cGMP,T3 and T4 in Yin-deficiency mice model.Methods The Yin-deficiency mice model induced by Thyroid Tablets and reserpine was used to study the drug action.All drugs were given orally once daily for seven days.Mice were administrated Thyroid Tablets and reserpine daily before the drug administration.Seven days later,growth rate of bo... |
| Keywords: | cAMP/cGMP |
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