| 益生菌Lb. casei Zhang对H22荷瘤小鼠化疗的减毒增效作用 |
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| 引用本文： | 王托娅,张和平. 益生菌Lb. casei Zhang对H22荷瘤小鼠化疗的减毒增效作用[J]. 内蒙古医学院学报, 2011, 33(2): 98-102 |
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| 作者姓名： | 王托娅 张和平 |
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| 作者单位： | 1. 内蒙古医学院附属医院,临床检验中心,内蒙古,呼和浩特,010050
2. 内蒙古农业大学乳品生物技术与工程实验室 |
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| 基金项目： | 国家自然基金项目，教育部科学技术研究重点项目，教育部春晖计划项目，内蒙古虚拟乳业研究院研究项目 |
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| 摘 要： | 目的：研究益生菌Lb.casei Zhang对荷H22肿瘤小鼠化疗的减毒增效作用。方法：以荷H22肝癌化疗小鼠为模型,以腹腔注射环磷酰胺（CTX）联用Lb.casei Zhang活菌制剂高、中、低三个剂量灌服小鼠12d后,计算脾指数和肿瘤生长抑制率,采用碘化丙啶（PI）染色利用流式细胞仪检测肿瘤细胞细胞周期和凋亡率。结果：益生菌Lb.casei Zhang对荷瘤鼠化疗所引起的免疫功能低下具有明显的恢复作用,Lb.casei Zhang具有协同增强CTX将肿瘤细胞周期阻滞于S期,抑制肿瘤细胞的增殖。结论：益生菌Lb.casei Zhang能够拮抗化疗所引起的免疫抑制,可以改善化疗荷瘤小鼠一般状况,提高其生存质量,协同增强化疗药物的抗肿瘤作用,具有明显的化疗减毒增效作用。
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| 关 键 词： | Lb. casei Zhang 小鼠肝癌H22 化疗 减毒 增效 |
SYNERGISTIC EFFECTS AND DECREASING TOXICITY OF PROBIOTICS Lb.casei Zhang ON H22TUMOR-BEARING MICE AFTER CHEMOTHERAPY |
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| Tuoya,ZHANG He-ping. SYNERGISTIC EFFECTS AND DECREASING TOXICITY OF PROBIOTICS Lb.casei Zhang ON H22TUMOR-BEARING MICE AFTER CHEMOTHERAPY[J]. Acta Academiae Medicinae Neimongol, 2011, 33(2): 98-102 |
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| Authors: | Tuoya ZHANG He-ping |
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| Affiliation: | Tuoya,ZHANG He-ping (Department of clinical test center,Affiliated hospital,Inner Mongolia Medical College,Hohhot 010050,China) |
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| Abstract: | Objective:To study the action of toxin-attenuating and efficacy-enhancing of Lb.casei Zhang in the chemotherapy to treat H22 tumor-bearing mice.Methods:Take H22 liver tumor-bearing mice as models,intraperitoneally injected cyclophosphamide combined with 12days'orally administration with three variety of dosages of living Lb.casei Zhang.Then calculating spleen index and tumor growth inhibition rate.Apply PI dying and Flow Cytometry to examine cell cycle and cell apoptosis rate of tumor cells.Results:Lb.casei... |
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| Keywords: | Lb. casei Zhang |
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