| MMP-2C-735T基因多态性与高血压伴颈动脉粥样硬化的关系 |
| |
| 引用本文： | 马岩萍,徐新娟,李孝华.MMP-2C-735T基因多态性与高血压伴颈动脉粥样硬化的关系[J].武警医学,2011,22(6):510-512. |
| |
| 作者姓名： | 马岩萍 徐新娟 李孝华 |
| |
| 作者单位： | 武警新疆总队医院高血压科,乌鲁木齐,830091;新疆医科大学第一附属医院高血压科,乌鲁木齐,830054 |
| |
| 摘 要： | 目的 研究基质金属蛋白酶-2(matrix metalloproteinase 2,MMP-2)C-735T与原发性高血压(essential hypertension,EH)伴颈动脉粥样硬化(carotid a山erosclerosis,CAS)的关系.方法 采用病例-对照研究,应用聚合酶链反应-限制性片断长度多态性(polymerase chain reaction-restiction fragment length polymorphism,PCR-RELP)技术测定MMP-2 C-735T基因多态性.结果 AS组的T等位基因频率明显高于NS组(X2=7.144,P=o.008).结论 MMP-2基因C-735T多态性可能与汉族EH患者伴CAS有关,T等位基因可能增加EH患者伴发CAS的风险.
|
| 关 键 词： | 基质金属蛋白酶-2 基因多态性 高血压 颈动脉粥样硬化 |
| 收稿时间： | 2011-01-05 |
Single nucleotide polymorphism of matrix metalloproteinase-2-735C/T is associated with essential hypertension accompanied by carotid atherosclerosis |
| |
| MA Yanping,XU Xinjuan,LI Xiaohua.Single nucleotide polymorphism of matrix metalloproteinase-2-735C/T is associated with essential hypertension accompanied by carotid atherosclerosis[J].Medical Journal of the Chinese People's Armed Police Forces,2011,22(6):510-512. |
| |
| Authors: | MA Yanping XU Xinjuan LI Xiaohua |
| |
| Institution: | MA Yanping~1,XU Xinjuan~2,and LI Xiaohua ~1.1.Department of Hypertension,Xinjiang Autonomous Regional Corps Hospital,Chinese People's Armed Police Forces,Urumchi 830091,China,2.Department of Hypertension,The First Affiliated Hospital,Xinjiang Medical University,Urumchi 830054 |
| |
| Abstract: | Objective To investigate the relationship between the single nucleotide polymorphism of matrix metalloproteinase -2 (MMP-2) -735C/T and essential hypertension accompanied by carotid atherosclerosis in Chinese Han population.Methods Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies were determined.Results Individuals with TT genotype were 2.244 times as likely to suffer from essential hypertension with carotid atherosclero... |
| |
| Keywords: | MMP-2 gene polymorphism essential hypertension atherosclerosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《武警医学》浏览原始摘要信息 |
| 点击此处可从《武警医学》下载免费的PDF全文 |
