早期高压氧治疗重度颅脑外伤患者的临床研究

目的：探讨高压氧早期治疗对重度颅脑损伤患者的治疗转归和血糖、肝功能的影响。方法：依入选与排除标准,随机选取46例重度颅脑损伤患者,在脑外伤后8~30天开始HBO治疗作为早期治疗组（A组）。同时随机选取符合标准的脑外伤患者46例,在脑外伤后31~60天开始HBO治疗作为对照组（B组）。两组患者分别在HBO治疗前1-2 d、治疗后第1个疗程、第3个疗程常规进行生命体征监测、血气、血糖、电解质、肝肾功能、血常规、尿常规等指标监测,并进行GCS评分,伤后6个月进行GOS分级。结果：人院时GCS评分,两组比较无显著差异,治疗后30 d与入院时比较,两组均有显著提高,而A组提高更显著。肝功能各值治疗前后A、B两组比较无显著差异。治疗前A组与B组血糖值比较差异无统计学意义;治疗后A组血糖值明显低于B组有显著性意义.GOS评分,A组与B组相比较,早期应用HBO治疗组患者（A组）预后改善具有显著性意义。结论：早期HBO治疗可以明显改善重度颅脑损伤患者临床状态,稳定血糖,提高患者的生活质量和治疗效果。

Clinical Study of Early Hyperbaric Oxygen Therapy of the Patients with Severe Craniocerebral Injury

Objective：To study the effect of early hyperbaric oxygen therapy on prognosis、blood sugar and liver function of the patients with severe craniocerebral injury.Methods： Based on the selected and exclusive standard,forty six with severe craniocerebral injury who began to do the HBO therapy 8-30 days after injury were divided at random into group A to be the early therapy group and then forty six suitable patients with traumatic brain injury began to do the HBO therapy 31-60 days after injury were divided into group B in the same way to be the compare group.Some indicators of the patients such as Vital signs monitoring,blood gas,blood sugar,electrolytes,liver and kidney function,blood routine,urine routine were monitored separately in the 1-2 days before HBO therapy,and in the first and the third course of treatment.GCS scores were assessed and then GOS was used to assess the patients 6 months after HBO treatment.Result： There is no significant difference in the GCS score between the two groups when just go into the hospital.After 30 days＇ treatment,both groups＇ score have significantly increased,while group A increased more significantly.there is no significant difference in the score of liver function between the two groups after treatment compared with Primary score.the blood glucose level in group A compared with group B showed no significant difference.After treatment,the blood glucose level in group A was significantly lower than the group B.the GOS score in group A compared with group B,early application of HBO treatment group（Group A） prognosis has significantly improved.Conclusion： The early HBO treatment can significantly improve the severe traumatic brain injury clinicaltatus,stable blood sugar and improve the quality of life and treatment.