| 高效液相色谱法测定注射用卡络磺纳中卡络磺纳的含量 |
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| 引用本文： | 刘伟,周伯庭,徐平声,李新中.高效液相色谱法测定注射用卡络磺纳中卡络磺纳的含量[J].中国药房,2005,16(15):1175-1176. |
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| 作者姓名： | 刘伟 周伯庭 徐平声 李新中 |
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| 作者单位： | 中南大学湘雅医院药剂科,长沙市,410008 |
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| 摘 要： | 目的:建立以高效液相色谱法测定注射用卡络磺钠含量的方法。方法:色谱柱为C18,流动相为0.12%磷酸二氢铵缓冲液-无水乙醇(925∶75),流速为0.8ml/min,检测波长为363nm,进样量为10μl,柱温为25℃。结果:卡络磺钠检测浓度在0.08865～0.4432mg/ml范围内线性关系良好(r=0.9999,n=5),平均回收率为99.89%(RSD=1.53%,n=9)。结论:本方法简便、快捷、准确、精密度高,可用于注射用卡络磺钠的质量控制。
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| 关 键 词： | 高效液相色谱法 注射用卡络磺钠 卡络磺钠 含量测定 |
| 文章编号： | 1001-0408（2005）15-1175-02 |
| 收稿时间： | 2004-09-13 |
| 修稿时间： | 2004-11-08 |
Determination of Carbazochrome Sodium Sulfonate in Carbazochrome Sodium Sulfonate for Injection by HPLC |
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| LIU Wei,ZHOU Boting,XU Pingsheng,LI Xinzhong.Determination of Carbazochrome Sodium Sulfonate in Carbazochrome Sodium Sulfonate for Injection by HPLC[J].China Pharmacy,2005,16(15):1175-1176. |
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| Authors: | LIU Wei ZHOU Boting XU Pingsheng LI Xinzhong |
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| Abstract: | OBJECTIVE:To establish a method for determination of carbazochrome sodium sulfonate for injection.METH_ ODS:C 18 was used as chromatographic column;the mobile phase consisted of0.12%ammonium dihydrogen phosphate buffer solution-absolute alcohol(925∶75)with detection wavelength at363nm and flow rate at0.8ml/min.The sample size was10μl and the column temperature was25℃.RESULTS:Linear relation was achieved when the concentration of carbzochrome sodium sulfonate was within the range of0.08865mg/ml～0.4432mg/ml(r=0.9999,n=5).The mean recovery rate was99.89%(RSD=1.53%,n=9).CONCLUSION:This method is simple,rapid,accurate,precise,and which can be used as the quality control of carbzochrome sodium sulfonate for injection. |
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| Keywords: | HPLC Carbazochrome sodium sulfnate for injection Carbazochrome sodium sulfonate Content determination |
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