Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial

Authors:	Barry Dixon Marcus J Schultz Roger Smith James B Fink John D Santamaria Duncan J Campbell

Affiliation:	(1) Department of Intensive Care, St. Vincent's Hospital, 41 Victoria Parade, Fitzroy, Melbourne, Victoria, 3065, Australia;(2) Department of Intensive Care Medicine & Laboratory of Experimental Intensive Care and Anesthesiology, The Academic Medical Center, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands;(3) Division of Respiratory Therapy, School of Health Professions, College of Health and Human Sciences, Georgia State University, 424 One Park Place South, Atlanta, GA 30302-4019, USA;(4) St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Melbourne, Victoria, 3065, Australia;(5) Department of Medicine, The University of Melbourne, Clinical Sciences Building 29 Regent Street, Fitzroy, Melbourne, Victoria, 3065, Australia

Abstract:	Introduction Prolonged mechanical ventilation has the potential to aggravate or initiate pulmonary inflammation and cause lung damage through fibrin deposition. Heparin may reduce pulmonary inflammation and fibrin deposition. We therefore assessed whether nebulized heparin improved lung function in patients expected to require prolonged mechanical ventilation.

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