氯雷他定柔性脂质体的制备及体外透皮研究

目的:制备氯雷他定柔性脂质体并研究该脂质体中氯雷他定的体外透皮情况.方法:用逆向蒸发法制备柔性脂质体,采用改良的Franz扩散池进行体外透皮吸收试验.结果:与普通脂质体相比较,柔性脂质体能提高氯雷他定的透皮速率.结论:柔性脂质体可显著促进氯雷他定的透皮吸收情况.

Preparation of Loratadine-loaded Ultraflexible Liposomes and Percutanous Penetration in vitro

Objective： To prepare ultraflexible liposomes of loratadine and study the permeation through the excised rat skin.Method： Reverse-phase evaporation method was used to prepare the ultraflexible liposomes,and in vitro skin permeation experiment was performed using modified Franz diffusion cells with excised rat skin as the barrier.Result： Compared with the ordinary liposomes,the ultraflexible liposomes could increase diffusion rate of loratadine through the skin of rats.Conclusion： Ultraflexible liposomes can significantly enhance the diffusion rate of loratadine through the skin of rats.