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| Strategies for myelin regeneration: lessons learned from development | |
| 引用本文： | Abhay Bhatt,Lir-Wan Fan,Yi Pang. Strategies for myelin regeneration: lessons learned from development[J]. 中国神经再生研究, 2014, 9(14): 21-24. DOI: 10.4103/1673-5374.137586 |
| 作者姓名： | Abhay Bhatt Lir-Wan Fan Yi Pang |
| 基金项目： | The work is supported by grants from NIH （RO1NS080844）, Michel J. Fox foundation, Intramural Research Support Program, and by funds from the Department of Pediatrics, University of Mississippi Medical Center. |
| 摘 要： | Myelin regeneration is indispensably important for patients suffering from several central nervous system （CNS） disorders such as multiple sclerosis （MS） and spinal cord injury （SCI）, because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understanding the cellular and molecular mechanisms underlying remyelination is critical for the development of remyelination-specific therapeutic approaches. As remyelination shares certain common mechanisms with developmental myelination, knowledge from study of developmental myelination contributes greatly to emerging myelin regeneration therapies, best evidenced as the recently developed human anti-Nogo receptor interacting protein-1 （LINGO-1） monoclonal antibodies to treat MS patients in clinical trials. |
| 关 键 词： | 髓鞘 再生 中枢神经系统 Nogo受体 分子机制 多发性硬化 神经生理学 单克隆抗体 |
Strategies for myelin regeneration： lessons learned from development |
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| Abhay Bhatt Lir-Wan Fan Yi Pang. Strategies for myelin regeneration： lessons learned from development[J]. Neural Regeneration Research, 2014, 9(14): 21-24. DOI: 10.4103/1673-5374.137586 | |
| Authors: | Abhay Bhatt Lir-Wan Fan Yi Pang |
| Affiliation: | Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS, USA |
| Abstract: | Myelin regeneration is indispensably important for patients suffering from several central nervous system (CNS) disorders such as multiple sclerosis (MS) and spinal cord injury (SCI), because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understanding the cellular and molecular mechanisms underlying remyelination is critical for the development of remyelination-specific therapeutic approaches. As remyelination shares certain common mechanisms with developmental myelination, knowledge from study of developmental myelination contributes greatly to emerging myelin regeneration therapies, best evidenced as the recently developed human anti-Nogo receptor interacting protein-1 (LINGO-1) monoclonal antibodies to treat MS patients in clinical trials. |
| Keywords: | oligodendrocyte myelination microglia multiple sclerosis white matter damage spinalcord injury |
| 本文献已被 CNKI 维普 等数据库收录！ | |