锌制剂防治小儿轮状病毒肠炎疗效观察

目的观察口服补锌对小儿轮状病毒(RV)肠炎的疗效。方法将6～24个月RV肠炎患儿共150例随机分成两组,干预组75例,对照组75例,两组均采用相同的常规治疗,干预组加用葡萄糖酸锌治疗。观察两组的临床疗效,治疗后1、2、3个月各随访1次观察两组患儿腹泻复发率及重型腹泻复发率。结果干预组显效54例,有效17例,无效4例,总有效率为94.67%;对照组显效41例,有效15例,无效19例,总有效率为74.67%。两组治疗效果差异有统计学意义(P<0.05)。治疗后1、2、3个月两组腹泻复发率比较差异均有统计学意义(P<0.05),3个月内重型腹泻复发率比较差异亦有统计学意义(P<0.05)。结论小儿RV肠炎在常规治疗方法上加用葡萄糖酸锌口服液可缓解症状、减轻病情,缩短腹泻病程,并能预防未来3个月内的腹泻复发,值得推广。

Therapeutic Effect of Zinc in the Prevention and Treatment of Children Rotavirus Enteritis

Objective To investigate the therapeutic effect of oral zinc supplementation in children rotavirus enteritis. Methods 150 cases of rotavirus enteritis of sick children from 6 to 24 months were randomly divided into two groups.The intervention group had 75 cases and the control group had 75 cases.Both groups were given the same conventional treatment and the intervention group was given additional Zinc Gluconate.The clinical therapeutic effect of the two groups was observed and the diarrhea rate and severity of the two groups after treatment were observed through one time follow up in the first,second and the third month after treatment. Results In intervention group,54 cases showed significant effect,17 cases showed effect,4 cases showed no effect,and the general effect rate was 94.67%;in control group,41 cases showed significant effect,15 cases showed effect,19 cases showed no effect and the general effect rate was 74.67%.The difference of the therapeutic effect between the two groups was statistically significant(P<0.05).The diarrhea rate of the two groups in the following up the first,second and third month after treatment showed statistically significant difference(P<0.05).The severe diarrhea rate of the two groups during the three months also showed statistically significant difference(P<0.05). Conclusion The children rotavirus enteritis can be relieved and the diarrhea process can be shortened by adding oral Zinc Gluconate on the basis of the conventional treatment.This can also prevent diarrhea from recurring in the following 3 months,for which this method is worth of promoting.