Effects of cyclooxygenase 2 inhibitor on growth-associated protein 43 and nerve growth factor expression in dorsal root ganglion during neuropathic pain development |
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| Authors: | Chen Wang Zhenwei Zheng |
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| Affiliation: | Chen Wang~1,Zhenwei Zheng~2 1 Department of Anesthesiology,Second Hospital of Xiamen,Xiamen 361021,Guangdong Province,China 2 Department of Anesthesiology,Second Affiliated Hospital of Shantou University Medical College,Shantou 515041,China |
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| Abstract: | BACKGROUND:Inflammatory responses in injured nerves have been recognized as important factors for initially sensitizing nociceptive neurons.Cyclooxygenase(COX) is the rate-limiting enzyme in prostaglandin synthesis,and COX-2 inhibitor is involved in mechanisms of analgesia and anti-inflammation. OBJECTIVE:To investigate the effects of COX-2 inhibitor on thermal and mechanical hyperalgesia, as well as expression of growth associated protein 43(GAP-43) and nerve growth factor(NGF) in dorsal root ganglion,in a... |
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| Keywords: | growth associated protein nerve growth factor neuropathic pain cyclooxygenase inhibitor Iomoxicam dorsal root ganglion |
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