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Chromatin condensation,fragmentation of DNA and differences in the epigenetic signature of infertile men
Affiliation:1. Department of Experimental, Clinical and Biomedical Sciences, Unit of Sexual Medicine and Andrology, Center of Excellence DeNothe, University of Florence, Viale Pieraccini, 6, I-50139, Firenze, Italy;2. Reproductive Medicine and Gynecological Endocrinology (RME), University Hospital, University of Basel, Vogesenstrasse 134, CH-4031, Basel, Switzerland;1. Department of Obstetrics, University Women''s Hospital, University of Basel, Basel, Switzerland;2. Reproductive Medicine and Gynecological Endocrinology (RME), University Hospital, University of Basel, Vogesenstrasse 124, 4031, Basel, Switzerland;3. Department of Biomedicine (DBM), University Hospital, University of Basel, Basel, Switzerland;4. Department of Obstetrics and Gynaecology, University Hospital Bern, Bern, Switzerland;1. Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium;2. Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University, Rua Cristóvão Colombo, 2265 Jardim Nazareth, 15054-000, São José do Rio Preto, São Paulo, Brazil;3. Department of Obstetrics and Gynaecology, Birmingham Women''s NHS Foundation Trust, Birmingham, United Kingdom;4. Tommy''s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom;5. Birmingham Women''s and Children''s NHS Foundation Trust, Mindelsohn Way, Birmingham, B15 2TG, United Kingdom;6. CARE Fertility Group, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham, NG8 6PZ, United Kingdom;1. Department of Reproductive Medicine, Dexeus University Hospital, Barcelona, Spain;2. Conceptum – Unidad de Fertilidad del Country, Bogotá, Colombia;3. Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark;4. Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium;1. Department of Gynecology-Andrology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium;2. Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Avenue Mounier 52, 1200 Brussels, Belgium
Abstract:
Keywords:sperm DNA fragmentation  chromatin condensation  epigenome  endocrine disruptors  male infertility
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