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Steady-state auditory evoked fields reflect long-term effects of repetitive transcranial magnetic stimulation in tinnitus |
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| Institution: | 1. Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou City, Guangdong Province, China;2. Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;3. Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;1. Neuroscience Program, University of Illinois, Champaign, IL 61820, USA;2. Department of Speech and Hearing Science, University of Illinois, Champaign, IL 61820, USA;3. College of Medicine, University of Illinois, Champaign, IL 61820, USA;4. Beckman Institute for Advanced Science and Technology, University of Illinois, Champaign, IL 61820, USA;1. Department of Neurological Surgery, University of Texas Southwestern, United States;2. Lab for Clinical and Integrative Neuroscience, Global Brain Health Institute, Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland;3. Department of Surgical Sciences, Section of Neurosurgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand;4. Lab for Clinical and Integrative Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, United States |
| Abstract: | ObjectivesEvidence of plastic changes in tinnitus has been demonstrated in functional brain imaging. Although repetitive transcranial magnetic stimulation (rTMS) has been shown to decrease steady-state auditory evoked fields (SSAEFs) in tinnitus, the long-term consequence remained unknown. In addition, association between plastic changes as reflected by hemispheric asymmetry and tinnitus handicap inventory (THI) before and after rTMS have not been addressed.MethodsTwelve tinnitus patients received rTMS and 12 received sham stimulation. Another 12 healthy participants served as the normal hearing controls. Patients responded to the THI before the 1st session and at one month after the final session of rTMS/sham stimulation. Changes in brain activity were assessed by measuring SSAEFs.ResultsSSAEFs remained decreased one month after rTMS compared to before treatment, along with a significant reduction in THI score. There was no significant effect between the index of hemispheric asymmetry and THI score.ConclusionsThe current study objectively demonstrated the long-term effects of rTMS on tinnitus using SSAEFs. A longitudinal study to develop an index using SSAEFs to assess the subjective severity of tinnitus is warranted.SignificanceThis study suggests the possible use of SSAEFs to assess the long-term effects of rTMS on tinnitus. |
| Keywords: | Idiopathic sudden sensorineural hearing loss (ISSNHL) Magnetoencephalography (MEG) Repetitive transcranial magnetic stimulation (rTMS) Steady-state auditory evoked fields (SSAEFs) Tinnitus |
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