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Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice
Authors:Guang-Hui Qiang  Zhong-Xia Wang  An-Lai Ji  Jun-Yi Wu  Yin Cao  Guang Zhang  Yi-Yang Zhang  Chun-Ping Jiang
Affiliation:1. Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, Drum Tower Clinical College of Nanjing Medical University, Nanjing 210008, China;2. Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China;3. Department of Gastroenterology, Nanjing Drum Tower Hospital, Drum Tower Clinical College of Nanjing Medical University, Nanjing 210008, China;1. Department of Surgery, Shiga General Hospital, Moriyama 524-8524, Japan;2. Department of Digestive Surgery, Tenriyorodusoudanjyo Hospital, Tenri 632-8552, Japan;3. Department of Hepato-Biliary-Pancreatic and Surgery and Transplantation, Kyoto University Hospital, Kyoto 606-8507, Japan;4. First Department of Surgery, Mie University Hospital, Tsu 514-8507, Japan;1. Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia;2. Department of Surgery, University of Melbourne, Northern Health, Epping, Victoria, Australia;3. Department of Anaesthesia, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia
Abstract:
Keywords:Ischemia/reperfusion injury  Sphingosine kinase 1  Inflammation  Oxidative stress
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